All Phenotypes Cul9<tm1.2Yxi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cul9^tm1.2Yxi
targeted mutation 1.2, Yue Xiong
MGI:5007737

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5007742
ht2	Cul9^tm1.2Yxi/Cul9⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5007741
cx3	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB/N	MGI:5007743
cx4	Cul9^tm1.2Yxi/Cul9⁺ Tg(IghMyc)22Bri/0	involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL	MGI:5007744
cx5	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi Tg(IghMyc)22Bri/0	involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL	MGI:5007745

Allelic Composition	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9^tm1.2Yxi mutation (0 available); any Cul9 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:170976 )

• 8 of 28 mice

increased ovary tumor incidence ( J:170976 )

• 1 of 12 mice

mortality/aging

decreased tumor-free survival time ( J:170976 )

• tumor-free survival is 19.9 months compared with 26.4 months for wild-type mice

liver/biliary system

increased liver tumor incidence ( J:170976 )

• 2 of 28 mice

neoplasm

increased tumor incidence ( J:170976 )

• 22 of 28 mice exhibit tumors including lymphoma, sarcoma, and tumors in the pituitary, lung, liver, and ovary

increased pituitary gland tumor incidence ( J:170976 )

• 8 of 28 mice

increased ovary tumor incidence ( J:170976 )

• 1 of 12 mice

increased incidence of tumors by chemical induction ( J:170976 )

• DEN-treated mice develop more tumors than similarly treated wild-type mice

increased liver tumor incidence ( J:170976 )

• 2 of 28 mice

increased lymphoma incidence ( J:170976 )

• 4 of 28 mice

increased sarcoma incidence ( J:170976 )

• 2 of 28 mice

increased lung tumor incidence ( J:170976 )

• 4 of 28 mice

cellular

cellular phenotype ( J:170976 )

N	• mouse embryonic fibroblasts exhibit normal cell cycle progression

decreased cellular sensitivity to gamma-irradiation ( J:170976 )

• in embryonic stem, thymus, and spleen cells

decreased cellular sensitivity to ultraviolet irradiation ( J:170976 )

• in mouse embryonic fibroblasts

nervous system

increased pituitary gland tumor incidence ( J:170976 )

• 8 of 28 mice

reproductive system

increased ovary tumor incidence ( J:170976 )

• 1 of 12 mice

growth/size/body

decreased body weight ( J:170976 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:170976 )

• DEN-treated mice develop more tumors than similarly treated wild-type mice

respiratory system

increased lung tumor incidence ( J:170976 )

• 4 of 28 mice

Allelic Composition	Cul9^tm1.2Yxi/Cul9⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9^tm1.2Yxi mutation (0 available); any Cul9 mutation (110 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pituitary gland tumor incidence ( J:170976 )

• 4 of 23 mice

increased insulinoma incidence ( J:170976 )

• in 1 of 23 mice

mortality/aging

decreased tumor-free survival time ( J:170976 )

• tumor-free survival is 20.8 months compared with 26.4 months for wild-type mice

neoplasm

increased tumor incidence ( J:170976 )

• 17 of 23 mice develop tumors along the same spectrum as homozygous mice

increased pituitary gland tumor incidence ( J:170976 )

• 4 of 23 mice

increased insulinoma incidence ( J:170976 )

• in 1 of 23 mice

increased incidence of tumors by chemical induction ( J:170976 )

• DEN-treated mice develop more tumors than similarly treated wild-type mice

increased lymphoma incidence ( J:170976 )

• in 3 of 23 mice

increased sarcoma incidence ( J:170976 )

• in 3 of 23 mice

increased lung tumor incidence ( J:170976 )

• 5 of 23 mice

nervous system

increased pituitary gland tumor incidence ( J:170976 )

• 4 of 23 mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:170976 )

• DEN-treated mice develop more tumors than similarly treated wild-type mice

respiratory system

increased lung tumor incidence ( J:170976 )

• 5 of 23 mice

Allelic Composition	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9^tm1.2Yxi mutation (0 available); any Cul9 mutation (110 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (240 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:170976 )

N	• mice exhibit the same tumors-free survival time as Trp53^tm1Tyj homozygotes

neoplasm

neoplasm ( J:170976 )

N	• mice exhibit the same tumors-free survival time as Trp53^tm1Tyj homozygotes

Allelic Composition	Cul9^tm1.2Yxi/Cul9⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9^tm1.2Yxi mutation (0 available); any Cul9 mutation (110 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170976 )

• lymphoma-free survival is 108.9 months compared with 126.4 months for Tg(IghMyc)22Bri mice

neoplasm

abnormal tumor pathology ( J:170976 )

• lymphoma cell clusters spread throughout the liver parenchyma and exhibit various degrees of lung and pancreas infiltration unlike in Tg(IghMyc)22Bri mice

increased lymphoma incidence ( J:170976 )

• 3 of 5 mice younger than 2 months of age develop lymphomas unlike Tg(IghMyc)22Bri mice

• by 5 months, 16 of 20 of mice develop lymphomas compared with 6 of 9 Tg(IghMyc)22Bri mice

increased B cell derived lymphoma incidence ( J:170976 )

• all lymphomas are B cell or pre-B cell lymphomas

Allelic Composition	Cul9^tm1.2Yxi/Cul9^tm1.2Yxi Tg(IghMyc)22Bri/0
Genetic Background	involves: 129P2/OlaHsd * C57BL * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cul9^tm1.2Yxi mutation (0 available); any Cul9 mutation (110 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:170976 )

• lymphoma-free survival is 85.1 months compared with 126.4 months for Tg(IghMyc)22Bri mice

neoplasm

abnormal tumor pathology ( J:170976 )

• lymphoma cell clusters spread throughout the liver parenchyma and exhibit various degrees of lung and pancreas infiltration unlike in Tg(IghMyc)22Bri mice

increased lymphoma incidence ( J:170976 )

• mice develop lymphomas by 25 days of age

• 3 of 5 mice younger than 2 months of age develop lymphomas unlike Tg(IghMyc)22Bri mice

• by 5 months, 10 of 10 of mice develop lymphomas compared with 6 of 9 Tg(IghMyc)22Bri mice

increased B cell derived lymphoma incidence ( J:170976 )

• all lymphomas are B cell or pre-B cell lymphomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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