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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl
targeted mutation 1, Merck Research Laboratory
MGI:5007772
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+ Not Specified MGI:5008583
cn2
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Ptentm1Hwu/Ptentm1Hwu
involves: 129S4/SvJae * C57BL/6 MGI:5008587
cn3
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:5008586
cx4
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+
involves: 129S4/SvJae * C57BL/6NTac MGI:5008591


Genotype
MGI:5008583
ht1
Allelic
Composition
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• doxycycline-treated mice exhibit impaired glucose clearance during intraperitoneal glucose tolerance test compared with wild-type mice
• in doxycycline-treated mice
• however, withdrawal of doxycycline restores glucose levels
• in doxycycline-treated mice




Genotype
MGI:5008587
cn2
Allelic
Composition
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sortm9(cre/ESR1)Arte
Ptentm1Hwu/Ptentm1Hwu
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• tamoxifen-treated mice survive 57 days unlike control mice

immune system
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice

neoplasm
• tamoxifen-treated mice develop T cell acute lymphoblastic leukemia unlike control mice

behavior/neurological
• in tamoxifen-treated mice

growth/size/body
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice

integument
• scruffy coat in tamoxifen-treated mice

hematopoietic system
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice
• in tamoxifen-treated mice




Genotype
MGI:5008586
cn3
Allelic
Composition
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu
Tg(Pbsn-cre)4Prb/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• in doxycycline-treated mice
• in doxycycline-treated mice
• in doxycycline-treated mice
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes

neoplasm
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes

endocrine/exocrine glands
• in doxycycline-treated mice
• in doxycycline-treated mice
• in doxycycline-treated mice
• doxycycline-treated mice exhibit microinvasive tumors in the prostate gland unlike in Pdk1tm1Dral homozygotes
• doxycycline-treated mice exhibit increased proliferation in the prostate gland compared to in Pdk1tm1Dral homozygotes




Genotype
MGI:5008591
cx4
Allelic
Composition
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl/Gt(ROSA)26Sor+
Ptentm1.1Hwu/Pten+
Genetic
Background
involves: 129S4/SvJae * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pdpk1)Mrl mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Ptentm1.1Hwu mutation (0 available); any Pten mutation (88 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• in doxycycline-treated mice
• at 6 to 7 months of age in doxycycline-treated mice

endocrine/exocrine glands
• in doxycycline-treated mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory