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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Masp2tm1Wjsc
targeted mutation 1, Wilhelm J Schwaeble
MGI:5007776
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Masp2tm1Wjsc/Masp2tm1Wjsc B6.129P2-Masp2tm1Wjsc MGI:5007777


Genotype
MGI:5007777
hm1
Allelic
Composition		 Masp2tm1Wjsc/Masp2tm1Wjsc
Genetic
Background		 B6.129P2-Masp2tm1Wjsc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Masp2tm1Wjsc mutation (0 available); any Masp2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Masp2tm1Wjsc/Masp2tm1Wjsc mice exhibit reduced myocardial ischemia/reperfusion injury-induced myocardial damage

homeostasis/metabolism
decreased susceptibility to injury ( J:172218 )
• significant protection from gastrointestinal ischemia/reperfusion injury
decreased myocardial infarct size ( J:172218 )
• significant reduction in myocardial ischemia/reperfusion injury-induced myocardial damage

immune system
impaired lectin complement pathway ( J:172218 )
• total absence of lectin pathway-dependent C4 cleavage on mannan- and zymosan-coated surfaces

cardiovascular system
decreased myocardial infarct size ( J:172218 )
• significant reduction in myocardial ischemia/reperfusion injury-induced myocardial damage




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory