Phenotypes associated with this allele

• Allele Symbol: Mefv^{tm4.1(MEFV)Chae}
• Allele Name: targeted mutation 4.1, Jae Jin Chae
• Allele ID: MGI:5007913
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mefv^tm4.1(MEFV)Chae/Mefv^tm4.1(MEFV)Chae	B6.129S6-Mefv^tm4.1(MEFV)Chae	MGI:5007927

Genotype
MGI:5007927

hm1

• Allelic Composition: Mefv^{tm4.1(MEFV)Chae}/Mefv^{tm4.1(MEFV)Chae}
• Genetic Background: B6.129S6-Mefv^{tm4.1(MEFV)Chae}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:172117 )

• mice exhibit increased CD11b+ cells compared with wild-type mice but not as much as in Mefv^{tm5.1(MEFV)Chae}

increased inflammatory response ( J:172117 )

• increased inflammatory phenotypes are less severe than in Mefv^{tm5.1(MEFV)Chae} homozygotes and Mefv^{tm3.1(MEFV)Chae} homozygotes

autoimmune arthritis ( J:172117 )

• after 20 weeks

dermatitis ( J:172117 )

• after 20 weeks

growth/size/body

decreased body weight ( J:172117 )

cachexia ( J:172117 )

• after 20 weeks

postnatal growth retardation ( J:172117 )

• after 20 weeks

integument

dermatitis ( J:172117 )

• after 20 weeks

skeleton

autoimmune arthritis ( J:172117 )

• after 20 weeks

hematopoietic system

increased leukocyte cell number ( J:172117 )

• mice exhibit increased CD11b+ cells compared with wild-type mice but not as much as in Mefv^{tm5.1(MEFV)Chae}

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial Mediterranean fever		DOID:2987	OMIM:134610 OMIM:249100	J:172117