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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pi4katm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:5008156
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pi4katm1.1Arte/Pi4katm1.1Arte C57BL/6NTac-Pi4katm1.1Arte MGI:5298109
cn2
 		Pi4katm1.1Arte/Pi4katm1.1Arte
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6NTac MGI:5444174


Genotype
MGI:5298109
hm1
Allelic
Composition		 Pi4katm1.1Arte/Pi4katm1.1Arte
Genetic
Background		 C57BL/6NTac-Pi4katm1.1Arte
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi4katm1.1Arte mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:172497 )
• mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities




Genotype
MGI:5444174
cn2
Allelic
Composition		 Pi4katm1.1Arte/Pi4katm1.1Arte
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Pi4katm1.1Arte mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188779 )
• within days of tamoxifen-induction

digestive/alimentary system
abnormal digestive system morphology ( J:188779 )
• following tamoxifen-induction, mucosal epithelial cells of the mucosae of the stomach and the small and large intestines exhibit widespread degeneration and necrosis compared with control mice
abnormal intestine morphology ( J:188779 )
• distended and filled with yellowish clear fluid following tamoxifen-induction
abnormal cecum morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit mucosal epithelial degeneration of cecal mucosa compared with control mice
abnormal duodenum morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit mucosal epithelial degeneration of duodenal mucosa compared with control mice
abnormal stomach mucosa morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit ulceration of nonglandular mucosa and parietal cell degeneration of glandular mucosa compared with control mice
abnormal gastric parietal cell morphology ( J:188779 )
• parietal cell degeneration of glandular mucosa following tamoxifen-induction
distended stomach ( J:188779 )
• distended and filled with food following tamoxifen-induction

endocrine/exocrine glands
abnormal gastric parietal cell morphology ( J:188779 )
• parietal cell degeneration of glandular mucosa following tamoxifen-induction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory