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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pi4katm2.1Arte
targeted mutation 2.1, TaconicArtemis
MGI:5008158
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pi4katm2.1Arte/Pi4katm2.1Arte involves: C57BL/6 * C57BL/6NTac MGI:5298110
cn2
 		Pi4katm2.1Arte/Pi4katm2.1Arte
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6NTac MGI:5444175
cn3
 		Pi4katm2.1Arte/Pi4ka+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: C57BL/6NTac MGI:5444176


Genotype
MGI:5298110
hm1
Allelic
Composition		 Pi4katm2.1Arte/Pi4katm2.1Arte
Genetic
Background		 involves: C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pi4katm2.1Arte mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:172498 )
• mice are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities




Genotype
MGI:5444175
cn2
Allelic
Composition		 Pi4katm2.1Arte/Pi4katm2.1Arte
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Pi4katm2.1Arte mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188779 )
• within 10 to 11 days of tamoxifen-induction

digestive/alimentary system
abnormal digestive system morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit widespread mucosal epithelial degeneration more so in the small and large intestines and less in the stomach compared with control mice
• however, mice do not exhibit a distended intestine morphology
diarrhea ( J:188779 )
• following tamoxifen-induction
abnormal small intestine crypts of Lieberkuhn morphology ( J:188779 )
• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction
abnormal large intestine morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit swollen and basophilic surface epithelial cells in the large intestine compared with control mice
abnormal large intestine crypts of Lieberkuhn morphology ( J:188779 )
• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction
abnormal small intestinal villus morphology ( J:188779 )
• following tamoxifen-induction, mice exhibit swollen villous epithelial cells with excessive vacuoles in the small intestine compared with control mice
abnormal digestion ( J:188779 )
• following tamoxifen-induction, mice exhibit loose or discolored intestine content

growth/size/body
decreased body size ( J:188779 )
• thin following tamoxifen-treatment

behavior/neurological
unresponsive to tactile stimuli ( J:188779 )
• in moribund mice following tamoxifen-induction
hunched posture ( J:188779 )
• following tamoxifen-treatment

integument
abnormal coat appearance ( J:188779 )
• poor coat condition following tamoxifen-treatment

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:188779 )
• loss of mucosal crypts in some areas of the large intestine following tamoxifen-induction
abnormal small intestine crypts of Lieberkuhn morphology ( J:188779 )
• focal atypical hyperplasia of mucosal crypts with small clusters of enlarged atypical crypts lined by tall dysplastic basophilic epithelial cells in the small intestine following tamoxifen-induction




Genotype
MGI:5444176
cn3
Allelic
Composition		 Pi4katm2.1Arte/Pi4ka+
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Pi4katm2.1Arte mutation (0 available); any Pi4ka mutation (126 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:188779 )
• 12 days following tamoxifen-treatment in male mice
• however, female mice remain normal

digestive/alimentary system
abnormal digestive system morphology ( J:188779 )
• following tamoxifen-treatment, male mice exhibit similar observations as in homozygous conditional knock-ins but with lower severity

behavior/neurological
hunched posture ( J:188779 )
• following tamoxifen-treatment in male mice
• however, female mice remain normal

growth/size/body
decreased body weight ( J:188779 )
• following tamoxifen-treatment in male mice
• however, female mice remain normal

hematopoietic system
abnormal spleen morphology ( J:188779 )
• following tamoxifen-treatment, one female mouse exhibited a black focal mild discoloration of the spleen

integument
abnormal coat appearance ( J:188779 )
• poor coat condition following tamoxifen-treatment in male mice
• however, female mice remain normal

immune system
abnormal spleen morphology ( J:188779 )
• following tamoxifen-treatment, one female mouse exhibited a black focal mild discoloration of the spleen




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory