Phenotypes associated with this allele

• Allele Symbol: Akr1b1^tm1.1Kgab
• Allele Name: targeted mutation 1.1, Kenneth H Gabbay
• Allele ID: MGI:5008171
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab	B6.Cg-Akr1b1^tm1.1Kgab	MGI:5008184
cx2	Akr1a1^Gt(OST222400)Lex/Akr1a1^Gt(OST222400)Lex Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab	B6.Cg-Akr1a1^Gt(OST222400)Lex Akr1b1^tm1.1Kgab	MGI:5008183

Genotype
MGI:5008184

hm1

• Allelic Composition: Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab
• Genetic Background: B6.Cg-Akr1b1^tm1.1Kgab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal vitamin C level ( J:164548 )

• male mice exhibit a decrease in liver and kidney ascorbate levels compared with wild-type mice

Genotype
MGI:5008183

cx2

• Allelic Composition: Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex}; Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab
• Genetic Background: B6.Cg-Akr1a1^{Gt(OST222400)Lex} Akr1b1^tm1.1Kgab

"Rachitic rosary" phenotype of Gulo^tm1Mae/Gulo^tm1Mae and Akr1b1^tm1.1Kgab/Akr1b1^tm1.1Kgab Akr1a1^{Gt(OST222400)Lex}/Akr1a1^{Gt(OST222400)Lex} bones

mortality/aging

premature death ( J:164548 )

• mice die at 8 to 10 weeks of age

skeleton

rachitic rosary ( J:164548 )

• newborn mice exhibit rapid onset of scurvy with ball-like swellings at the costochondral junction of the ribs resulting from hemorrhage and callus formation due to profound ascorbate deficiency