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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stim2tm1.1Kuro
targeted mutation 1.1, Tomohiro Kurosaki
MGI:5008479
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Stim1tm1Kuro/Stim1tm1Kuro
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 MGI:5008567
cn2
 		Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c * C57BL/6 MGI:5008568


Genotype
MGI:5008567
cn1
Allelic
Composition		 Stim1tm1Kuro/Stim1tm1Kuro
Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Stim1tm1Kuro mutation (0 available); any Stim1 mutation (47 available)
Stim2tm1.1Kuro mutation (0 available); any Stim2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

immune system
immune system phenotype ( J:172608 )
N
• mice exhibit normal B cell development
increased CD4-positive, alpha-beta T cell number ( J:172608 )
• following immunization with MOG35-55
increased CD8-positive, alpha-beta T cell number ( J:172608 )
• following immunization with MOG35-55
increased regulatory T cell number ( J:172608 )
• following immunization with MOG35-55
abnormal B cell physiology ( J:172608 )
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
decreased B cell proliferation ( J:172608 )
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice
increased interferon-gamma secretion ( J:172608 )
• in splenocytes following immunization with MOG35-55
decreased interleukin-10 secretion ( J:172608 )
• following stimulation with PMA and ionomycin, LPS, anti-IgM and anti-CD40, or anti-IgM and LPS
increased interleukin-10 secretion ( J:172608 )
• in splenocytes following immunization with MOG35-55
increased interleukin-17 secretion ( J:172608 )
• in splenocytes following immunization with MOG35-55
increased susceptibility to experimental autoimmune encephalomyelitis ( J:172608 )
• following immunization with MOG35-55, mice exhibit increased inflammatory cells infiltration (CD8+ and CD4+ T cells, T regulatory cells), demyelination, and cytokine production (IFN-gamma, IL17, and IL10) compared with control mice

nervous system
demyelination ( J:172608 )
• following immunization with MOG35-55

hematopoietic system
increased CD4-positive, alpha-beta T cell number ( J:172608 )
• following immunization with MOG35-55
increased CD8-positive, alpha-beta T cell number ( J:172608 )
• following immunization with MOG35-55
increased regulatory T cell number ( J:172608 )
• following immunization with MOG35-55
abnormal B cell physiology ( J:172608 )
• B cells treated with anti-IgM, anti-IgM and IL4, or anti-IgM and anti-CD40 exhibit reduced survival compared with control cells
• however, B cell treated with anti-CD40 or LPS exhibit normal survival and B cell antibody response is normal
decreased B cell proliferation ( J:172608 )
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit little calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

cellular
decreased B cell proliferation ( J:172608 )
• B cells treated anti-IgM fail to exhibit proliferation unlike control cells
• B cells treated anti-IgM and IL4 exhibit reduced proliferation compared with control cells
• however, B cell proliferation stimulated by anti-CD40 or LPS is normal




Genotype
MGI:5008568
cn2
Allelic
Composition		 Stim2tm1.1Kuro/Stim2tm1.1Kuro
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Stim2tm1.1Kuro mutation (0 available); any Stim2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172608 )
N
• B cell proliferation in response to anti-IgM, anti-CD40, and LPS is normal
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

homeostasis/metabolism
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice

hematopoietic system
abnormal B cell calcium ion homeostasis ( J:172608 )
• B cells exhibit a mild decrease in calcium ion influx after treatment with thapsigargin or anti-IgM compared with control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory