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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PDGFB-UCHL1*I93M)LWada
transgene insertion L, Keiji Wada
MGI:5008736
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(PDGFB-UCHL1*I93M)LWada/0 involves: C57BL/6J MGI:5008739


Genotype
MGI:5008739
tg1
Allelic
Composition		 Tg(PDGFB-UCHL1*I93M)LWada/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:128045 )
N
• in the absence of MPTP treatment no loss of dopaminergic neurons is detected unlike in mice carrying Tg(PDGFB-UCHL1*I93M)HWada
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

homeostasis/metabolism
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls

cellular
increased susceptibility to dopaminergic neuron neurotoxicity ( J:128045 )
• increase in dopaminergic neuron loss following MPTP treatment compared to non-transgenic controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory