About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-cre)1Dlam
transgene insertion 1, Diether Lambrechts
MGI:5009038
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0 		involves: 129 * C57BL/6 * FVB MGI:5013928
cn2
 		Gt(ROSA)26Sortm2(VEGFB*)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0 		involves: 129 * C57BL/6 * FVB MGI:5013929


Genotype
MGI:5013928
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam mutation (0 available); any Gt(ROSA)26Sor mutation (991 available)
Tg(Thy1-cre)1Dlam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sensory capabilities/reflexes/nociception ( J:172783 )
• 4 days following four paclitaxel injections to the hind paw, about 80% of mice respond to a pinprick stimulus compared to only 20% of wild type; overexpression of Flt1 is protective for sensory neurons to a distal neuropathy




Genotype
MGI:5013929
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(VEGFB*)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(VEGFB*)Dlam mutation (0 available); any Gt(ROSA)26Sor mutation (991 available)
Tg(Thy1-cre)1Dlam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:172783 )
N
• mice have a normal pattern of sensory axons in the hind paw
• neuronal overexpression of VEGFB186 significantly protects against neuropathy induced by a high dose of paclitaxel

cardiovascular system
abnormal developmental vascular remodeling ( J:172783 )
• mice have a normal vasculature in the hindlimb




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory