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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-cre)1Dlam
transgene insertion 1, Diether Lambrechts
MGI:5009038
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0 		involves: 129 * C57BL/6 * FVB MGI:5013928
cn2
 		Gt(ROSA)26Sortm2(VEGFB*)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0 		involves: 129 * C57BL/6 * FVB MGI:5013929


Genotype
MGI:5013928
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Flt1,EGFP)Dlam mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Thy1-cre)1Dlam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal sensory capabilities/reflexes/nociception ( J:172783 )
• 4 days following four paclitaxel injections to the hind paw, about 80% of mice respond to a pinprick stimulus compared to only 20% of wild type; overexpression of Flt1 is protective for sensory neurons to a distal neuropathy




Genotype
MGI:5013929
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(VEGFB*)Dlam/Gt(ROSA)26Sor+
Tg(Thy1-cre)1Dlam/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(VEGFB*)Dlam mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Thy1-cre)1Dlam mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:172783 )
N
• mice have a normal pattern of sensory axons in the hind paw
• neuronal overexpression of VEGFB186 significantly protects against neuropathy induced by a high dose of paclitaxel

cardiovascular system
abnormal developmental vascular remodeling ( J:172783 )
• mice have a normal vasculature in the hindlimb




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory