All Phenotypes Notch1<tm4(cre)Rko> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch1^tm4(cre)Rko
targeted mutation 4, Raphael Kopan
MGI:5009236

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Notch1^tm2Rko/Notch1^tm4(cre)Rko	involves: 129X1/SvJ * C57BL/6	MGI:5009540

Allelic Composition	Notch1^tm2Rko/Notch1^tm4(cre)Rko
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2Rko mutation (3 available); any Notch1 mutation (115 available)
Notch1^tm4(cre)Rko mutation (1 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Embryonic lethality in Notch1^tm2Rko/Notch1^tm4(cre)Rko embryos due to the failure of angiogenic remodeling

embryo

abnormal vitelline vasculature morphology ( J:171829 )

• defective angiogenic remodeling of the yolk sac vasculature is observed

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171829 )

• death at E10.5 is observed, likely resulting from higher loss of heterozygosity (LOH) frequency compared to that in Notch1^tm2Rko/Notch1^tm3(cre)Rko embryos; higher LOH occurs because of improved cre expression

cardiovascular system

abnormal vitelline vasculature morphology ( J:171829 )

• defective angiogenic remodeling of the yolk sac vasculature is observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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