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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Etv2tm2.1Dlim
targeted mutation 2.1, Dae-Sik Lim
MGI:5009241
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Etv2tm2.1Dlim/Etv2tm2.1Dlim involves: 129S4/SvJaeSor * C57BL/6 MGI:5009246
cn2
 		Etv2tm1Dlim/Etv2tm2.1Dlim
Tg(Mx1-cre)1Cgn/0 		involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:5009245


Genotype
MGI:5009246
hm1
Allelic
Composition		 Etv2tm2.1Dlim/Etv2tm2.1Dlim
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv2tm2.1Dlim mutation (0 available); any Etv2 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:172687 )
• mice are viable and phenotypically normal




Genotype
MGI:5009245
cn2
Allelic
Composition		 Etv2tm1Dlim/Etv2tm2.1Dlim
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv2tm1Dlim mutation (0 available); any Etv2 mutation (14 available)
Etv2tm2.1Dlim mutation (0 available); any Etv2 mutation (14 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
impaired myelopoiesis ( J:172687 )
• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice
decreased bone marrow cell number ( J:172687 )
• in pIpC-treated mice
abnormal myeloblast morphology/development ( J:172687 )
• pIpC-treated mice exhibit a decrease in the number of granulocyte-monocyte progenitors in the bone marrow compared with control mice
decreased leukocyte cell number ( J:172687 )
• slight in the peripheral blood of pIpC-treated mice
decreased hematopoietic stem cell number ( J:172687 )
• pIpC-treated mice exhibit reduced LSK cells, long-term hematopoietic stem cells, and short-term hematopoietic stem cells compared with control mice
spleen hypoplasia ( J:172687 )
• in pIpC-treated mice
abnormal hematopoietic stem cell physiology ( J:172687 )
• pIpC-treated mice exhibit increased apoptosis and decreased proliferation of LSK cells compared with control mice
• hematopoietic stem cells from pIpC-treated mice exhibit reduced repopulation capacity compared with cells from control mice

immune system
impaired myelopoiesis ( J:172687 )
• pIpC-treated mice exhibit a slightly decreased in the number of myeloid cells in the bone marrow and peripheral blood compared with control mice
decreased leukocyte cell number ( J:172687 )
• slight in the peripheral blood of pIpC-treated mice
spleen hypoplasia ( J:172687 )
• in pIpC-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory