Phenotypes associated with this allele

• Allele Symbol: Shox2^{tm2.1(SHOX_a)Ypc}
• Allele Name: targeted mutation 2.1, YiPing Chen
• Allele ID: MGI:5009258
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shox2^tm2.1(SHOX_a)Ypc/Shox2^tm2.1(SHOX_a)Ypc	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5009261

Genotype
MGI:5009261

hm1

• Allelic Composition: Shox2^{tm2.1(SHOX_a)Ypc}/Shox2^{tm2.1(SHOX_a)Ypc}
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Shox2^{tm2.1(SHOX_a)Ypc}/Shox2^{tm2.1(SHOX_a)Ypc} mice develop a severe wasting syndrome

craniofacial

abnormal temporomandibular joint disk morphology ( J:172674 )

• premature wear out of the articulating disc of the temporomandibular joint

• by P5 and P10 the articulating disc becomes much thinner than in controls

• at P21 the articulating disc is almost worn away

mortality/aging

postnatal lethality, incomplete penetrance ( J:172674 )

• only 14% (4 of 29) of mice survive to weaning

growth/size/body

slow postnatal weight gain ( J:172674 )

• develop a severe wasting syndrome

• however, weights are similar at birth

• if mice are fed liquid foods mice can slowly catch up with controls

skeleton

abnormal temporomandibular joint disk morphology ( J:172674 )

• premature wear out of the articulating disc of the temporomandibular joint

• by P5 and P10 the articulating disc becomes much thinner than in controls

• at P21 the articulating disc is almost worn away

cardiovascular system

cardiovascular system phenotype ( J:172674 )

N • normal heart rate unlike mice homozygous for Shox2^{tm2(SHOX_a)Ypc}

N • no defects in the sinoatrial node and sinus valves, unlike in null mice