All Phenotypes Atg3<tm1.1Ywh> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6	MGI:5009307
cn2	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:5806734
cn3	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Tg(Lck-cre)548Jxm/0	involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5009306

Allelic Composition	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3^tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:172749 )

• following tamoxifen stimulation

• however, apoptosis is rescued by IL7 treatment

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

hematopoietic system

increased T cell apoptosis ( J:172749 )

• following tamoxifen stimulation

• however, apoptosis is rescued by IL7 treatment

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

cellular

increased T cell apoptosis ( J:172749 )

• following tamoxifen stimulation

• however, apoptosis is rescued by IL7 treatment

Allelic Composition	Atg3^tm1.1Ywh/Atg3^tm1.1Ywh Fnip1^m1Btlr/Fnip1^m1Btlr Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg3^tm1.1Ywh mutation (0 available); any Atg3 mutation (19 available)
Fnip1^m1Btlr mutation (0 available); any Fnip1 mutation (60 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

cellular

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

hematopoietic system

absent B cells ( J:234285 )

• in the spleen and bone marrow B cell subsets of tamoxifen-treated mice

homeostasis/metabolism

abnormal autophagy ( J:234285 )

• tamoxifen-treated B cell precursors fail to exhibit an increase in bafilomycin-induced autophagy unlike in control cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired autophagy ( J:172749 )

• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells

immune system

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

thymus hypoplasia ( J:172749 )

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

spleen hypoplasia ( J:172749 )

cellular

impaired autophagy ( J:172749 )

• T cells stimulated with anti-CD3 antibodies exhibit impaired autophagy compared with wild-type cells

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

oxidative stress ( J:172749 )

• T cells exhibit overproduction of reactive oxygen species compared with wild-type cells

hematopoietic system

increased T cell apoptosis ( J:172749 )

• in the spleen

decreased T cell proliferation ( J:172749 )

• of T cells stimulated with anti-CD3 antibodies

thymus hypoplasia ( J:172749 )

abnormal T cell morphology ( J:172749 )

• T lymphocytes exhibit increased mitochondria and endoplasmic reticulum content compared with wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:172749 )

• in the spleen

spleen hypoplasia ( J:172749 )

endocrine/exocrine glands

thymus hypoplasia ( J:172749 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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