Phenotypes associated with this allele

• Allele Symbol: Syce3^tm1Rben
• Allele Name: targeted mutation 1, Ricardo Benavente
• Allele ID: MGI:5009455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syce3^tm1Rben/Syce3^tm1Rben	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5009456

Genotype
MGI:5009456

hm1

• Allelic Composition: Syce3^tm1Rben/Syce3^tm1Rben
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disruption of meiosis in Syce3^tm1Rben/Syce3^tm1Rben mice

reproductive system

abnormal meiosis ( J:172714 )

abnormal chromosomal synapsis ( J:172714 )

• autosomes are paired but sex chromosomes are frequently unpaired

• pairing and alignment are more severely affected in oocytes compared to spermatocytes

abnormal female meiosis ( J:172714 )

♀ • persistence of unrepaired double strand breaks

♀ • processing of transitional nodules to late recombination nodules is impaired

abnormal synaptonemal complex ( J:172714 )

• axial elements completely fail to synapse in pachytene-like spermatocytes and oocytes

• partially aligned axial elements lacking central element structures are seen in spermatocytes

abnormal ovary morphology ( J:172714 )

♀

absent mature ovarian follicles ( J:172714 )

♀

small ovary ( J:172714 )

♀

small testis ( J:172714 )

♂

abnormal spermatogenesis ( J:172714 )

♂ • programmed cell death at stage IV

azoospermia ( J:172714 )

♂ • no post meiotic cells are detected

abnormal male meiosis ( J:172714 )

♂ • many apoptotic meiotic cells and no post meiotic cells are detected

♂ • a marker of double strand breaks fails to be confined to the sex chromosomes during pachytene-like stages and persists into advanced stages of prophase suggesting a defect in double strand break repair

♂ • processing of transitional nodules to late recombination nodules is impaired

arrest of spermatogenesis ( J:172714 )

♂ • arrest during pachytene

female infertility ( J:172714 )

♀

male infertility ( J:172714 )

♂

endocrine/exocrine glands

abnormal ovary morphology ( J:172714 )

♀

absent mature ovarian follicles ( J:172714 )

♀

small ovary ( J:172714 )

♀

small testis ( J:172714 )

♂

cellular

azoospermia ( J:172714 )

♂ • no post meiotic cells are detected

abnormal meiosis ( J:172714 )

abnormal chromosomal synapsis ( J:172714 )

• autosomes are paired but sex chromosomes are frequently unpaired

• pairing and alignment are more severely affected in oocytes compared to spermatocytes

abnormal female meiosis ( J:172714 )

♀ • persistence of unrepaired double strand breaks

♀ • processing of transitional nodules to late recombination nodules is impaired

abnormal male meiosis ( J:172714 )

♂ • many apoptotic meiotic cells and no post meiotic cells are detected

♂ • a marker of double strand breaks fails to be confined to the sex chromosomes during pachytene-like stages and persists into advanced stages of prophase suggesting a defect in double strand break repair

♂ • processing of transitional nodules to late recombination nodules is impaired

abnormal synaptonemal complex ( J:172714 )

• axial elements completely fail to synapse in pachytene-like spermatocytes and oocytes

• partially aligned axial elements lacking central element structures are seen in spermatocytes