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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(Rnf187)Jhai
targeted mutation 2, Jody Haigh
MGI:5013401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Tg(Vil1-cre)20Syr/0 		involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5013409
cn2
 		ApcMin/Apc+
Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+
Tg(Vil1-cre)20Syr/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA/2 MGI:5013408


Genotype
MGI:5013409
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Rnf187)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal enterocyte proliferation ( J:173145 )
• mice exhibit increased cell proliferation in the colonic crypt compared with wild-type mice

cellular
abnormal enterocyte proliferation ( J:173145 )
• mice exhibit increased cell proliferation in the colonic crypt compared with wild-type mice




Genotype
MGI:5013408
cn2
Allelic
Composition		 ApcMin/Apc+
Gt(ROSA)26Sortm2(Rnf187)Jhai/Gt(ROSA)26Sor+
Tg(Vil1-cre)20Syr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (158 available)
Gt(ROSA)26Sortm2(Rnf187)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (997 available)
Tg(Vil1-cre)20Syr mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:173145 )
• intestinal tumors are increased in number compared to in ApcMin/Apc+ Tg(Vil-cre)20Syr
increased tumor growth/size ( J:173145 )
• intestinal tumors exhibit increased cell proliferation and size compared to in ApcMin/Apc+ Tg(Vil-cre)20Syr

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:173145 )
• intestinal tumors are increased in number compared to in ApcMin/Apc+ Tg(Vil-cre)20Syr




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory