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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dkk1tm1.1Svo
targeted mutation 1.1, Seppo Vainio
MGI:5013423
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Wnt4tm2(EGFP/cre)Svo/Wnt4+
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5013425
cn2
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax8tm1.1(cre)Mbu/Pax8+
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5013426
cn3
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax3tm1(cre)Joe/Pax3+
involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:5013427


Genotype
MGI:5013425
cn1
Allelic
Composition
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Wnt4tm2(EGFP/cre)Svo mutation (1 available); any Wnt4 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• mice exhibit normal kidneys




Genotype
MGI:5013426
cn2
Allelic
Composition
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax8tm1.1(cre)Mbu/Pax8+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Pax8tm1.1(cre)Mbu mutation (1 available); any Pax8 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• mice exhibit increased proliferation of epithelial tubules of the developing kidney papilla compared with wild-type mice
• mice exhibit increased chloride in the urine compared with wild-type mice
• mice exhibit hypertrophic collecting duct epithelial cells at the tip of the extended renal papilla compared with wild-type mice
• mice exhibit overgrowth of renal papilla in proportion to the rest of the kidney unlike in wild-type mice
• the papilla in the medulla extends over the lateral edge of the kidney capsule and reached the epithelial lining of the lumen of the ureter outside the kidney unlike in wild-type mice
• 7 of 10 mice exhibit over extended papilla unlike in wild-type mice
• in 2 of 10 mice

homeostasis/metabolism
• mice exhibit increased chloride in the urine compared with wild-type mice

cellular
• mice exhibit increased proliferation of epithelial tubules of the developing kidney papilla compared with wild-type mice




Genotype
MGI:5013427
cn3
Allelic
Composition
Dkk1tm1.1Svo/Dkk1tm1.2Svo
Pax3tm1(cre)Joe/Pax3+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Pax3tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo

craniofacial
• craniofacial development is truncated compared to in wild-type mice

renal/urinary system
N
• mice exhibit normal kidneys





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory