All Phenotypes Dkk1<tm1.2Svo> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013425
cn2	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Pax8^{tm1.1(cre)Mbu}/Pax8⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013426
cn3	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Pax3^tm1(cre)Joe/Pax3⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013427

Allelic Composition	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1^tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:173125 )

N	• mice exhibit normal kidneys

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased kidney cell proliferation ( J:173125 )

• mice exhibit increased proliferation of epithelial tubules of the developing kidney papilla compared with wild-type mice

decreased urine creatinine level ( J:173125 )

decreased urine glucose level ( J:173125 )

increased urine calcium level ( J:173125 )

increased urine chloride ion level ( J:173125 )

• mice exhibit increased chloride in the urine compared with wild-type mice

decreased urine potassium level ( J:173125 )

decreased urine sodium level ( J:173125 )

decreased urine phosphate level ( J:173125 )

decreased urine protein level ( J:173125 )

abnormal kidney collecting duct epithelium morphology ( J:173125 )

• mice exhibit hypertrophic collecting duct epithelial cells at the tip of the extended renal papilla compared with wild-type mice

abnormal kidney medulla morphology ( J:173125 )

elongated kidney papilla ( J:173125 )

• mice exhibit overgrowth of renal papilla in proportion to the rest of the kidney unlike in wild-type mice

• the papilla in the medulla extends over the lateral edge of the kidney capsule and reached the epithelial lining of the lumen of the ureter outside the kidney unlike in wild-type mice

• 7 of 10 mice exhibit over extended papilla unlike in wild-type mice

hydronephrosis ( J:173125 )

• in 2 of 10 mice

oliguria ( J:173125 )

homeostasis/metabolism

decreased urine creatinine level ( J:173125 )

decreased urine glucose level ( J:173125 )

increased urine calcium level ( J:173125 )

increased urine chloride ion level ( J:173125 )

• mice exhibit increased chloride in the urine compared with wild-type mice

decreased urine potassium level ( J:173125 )

decreased urine sodium level ( J:173125 )

decreased urine phosphate level ( J:173125 )

decreased urine protein level ( J:173125 )

cellular

increased kidney cell proliferation ( J:173125 )

• mice exhibit increased proliferation of epithelial tubules of the developing kidney papilla compared with wild-type mice

Allelic Composition	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1.1Svo mutation (1 available); any Dkk1 mutation (18 available)
Dkk1^tm1.2Svo mutation (0 available); any Dkk1 mutation (18 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:173125 )

embryo

caudal body truncation ( J:173125 )

craniofacial

abnormal craniofacial development ( J:173125 )

• craniofacial development is truncated compared to in wild-type mice

renal/urinary system

renal/urinary system phenotype ( J:173125 )

N	• mice exhibit normal kidneys

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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