Phenotypes associated with this allele

• Allele Symbol: Pax9^{tm1.1(Osr2)Jian}
• Allele Name: targeted mutation 1.1, Rulang Jiang
• Allele ID: MGI:5013428
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax9^tm1.1(Osr2)Jian/Pax9^tm1.1(Osr2)Jian	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:5013434
cx2	Osr2^tm1Jian/Osr2^tm1Jian Pax9^tm1.1(Osr2)Jian/Pax9^+	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:5013438

Genotype
MGI:5013434

hm1

• Allelic Composition: Pax9^{tm1.1(Osr2)Jian}/Pax9^{tm1.1(Osr2)Jian}
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:173121 )

• mice die shortly after birth

craniofacial

abnormal craniofacial bone morphology ( J:173121 )

arrest of tooth development ( J:173121 )

• at bud stage

abnormal mandible morphology ( J:173121 )

• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice

absent mandibular coronoid process ( J:173121 )

small mandible ( J:173121 )

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )

skeleton

abnormal craniofacial bone morphology ( J:173121 )

arrest of tooth development ( J:173121 )

• at bud stage

abnormal mandible morphology ( J:173121 )

• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice

absent mandibular coronoid process ( J:173121 )

small mandible ( J:173121 )

limbs/digits/tail

preaxial polydactyly ( J:173121 )

digestive/alimentary system

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )

hearing/vestibular/ear

decreased tympanic ring size ( J:173121 )

growth/size/body

arrest of tooth development ( J:173121 )

• at bud stage

abnormal palatal shelf morphology ( J:173121 )

• at E13.5, the palatal shelves are broadened compared to in wild-type mice

palatal shelves fail to meet at midline ( J:173121 )

• at E15.5

cleft secondary palate ( J:173121 )

Genotype
MGI:5013438

cx2

• Allelic Composition: Osr2^tm1Jian/Osr2^tm1Jian; Pax9^{tm1.1(Osr2)Jian}/Pax9⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

craniofacial

abnormal tooth development ( J:173121 )

• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice

• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice

• however, the number of teeth in the mandible is normal

cleft secondary palate ( J:173121 )

• in all mice

digestive/alimentary system

cleft secondary palate ( J:173121 )

• in all mice

growth/size/body

abnormal tooth development ( J:173121 )

• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice

• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice

• however, the number of teeth in the mandible is normal

cleft secondary palate ( J:173121 )

• in all mice

skeleton

abnormal tooth development ( J:173121 )

• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice

• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice

• however, the number of teeth in the mandible is normal