Phenotypes associated with this allele

• Allele Symbol: Ltbr^tm1Mmat
• Allele Name: targeted mutation 1, Mitsuru Matsumoto
• Allele ID: MGI:5013450
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltbr^tm1Mmat/Ltbr^tm1Mmat	involves: C57BL/6 * CBA	MGI:5013459
cx2	Cd40^tm1Kik/Cd40^tm1Kik Ltbr^tm1Mmat/Ltbr^tm1Mmat	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5013463
cx3	Ltbr^tm1Mmat/Ltbr^tm1Mmat Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5013465

Genotype
MGI:5013459

hm1

• Allelic Composition: Ltbr^tm1Mmat/Ltbr^tm1Mmat
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

• mice exhibit reduced percentage of UEA-1+ mTEC compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low mTEC compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

abnormal spleen morphology ( J:173115 )

absent spleen germinal center ( J:173115 )

absent follicular dendritic cells ( J:173115 )

absent mesenteric lymph nodes ( J:173115 )

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

• mice exhibit reduced percentage of UEA-1+ mTEC compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low mTEC compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

abnormal lymphocyte morphology ( J:173115 )

• mice exhibit accumulation of lymphoid cell aggregates (B220+, CD4+, and CD8+ lymphocytes) in the liver and lung unlike in wild-type mice

abnormal spleen morphology ( J:173115 )

absent spleen germinal center ( J:173115 )

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

• mice exhibit reduced percentage of UEA-1+ mTEC compared with wild-type mice

• mice exhibit reduced MHC II^high and MHC II^low mTEC compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

small thymus medulla ( J:173115 )

Genotype
MGI:5013463

cx2

• Allelic Composition: Cd40^tm1Kik/Cd40^tm1Kik; Ltbr^tm1Mmat/Ltbr^tm1Mmat
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

immune system

immune system phenotype ( J:173115 )

N • unlike Ltbr^tm1Mmat homozygotes, mice do not exhibit lymphoid cell aggregates

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit fewer MHC II^low medullary thymic epithelial cells compared to in wild-type mice

• mice exhibit fewer Aire+ medullary epithelial cells compared with wild-type mice

abnormal thymus medulla morphology ( J:173115 )

• medullary areas are smaller in size and less frequently connected to each other than in wild-type mice

Genotype
MGI:5013465

cx3

• Allelic Composition: Ltbr^tm1Mmat/Ltbr^tm1Mmat; Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

immune system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit more severe reduction medullary thymic epithelial cells (mTEC) than either single homozygote

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

hematopoietic system

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit more severe reduction medullary thymic epithelial cells (mTEC) than either single homozygote

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice

endocrine/exocrine glands

abnormal thymus epithelium morphology ( J:173115 )

• mice exhibit more severe reduction medullary thymic epithelial cells (mTEC) than either single homozygote

• mice exhibit fewer Aire+ medullary epithelial cells (mTEC) compared with wild-type mice