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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hormad1tm1Atot
targeted mutation 1, Attila Toth
MGI:5013479
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hormad1tm1Atot/Hormad1tm1Atot involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:5013558
cx2
 		Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1Atot/Hormad1tm1Atot 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5013560
cx3
 		Hormad1tm1Atot/Hormad1tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd MGI:5013559


Genotype
MGI:5013558
hm1
Allelic
Composition		 Hormad1tm1Atot/Hormad1tm1Atot
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Atot mutation (0 available); any Hormad1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173089 )
N
• oocyte numbers are normal
azoospermia ( J:173089 )
• male mice lack post-meiotic cells
abnormal chiasmata formation ( J:173089 )
• oocytes contain fewer chiasmata than wild-type cells
abnormal female meiosis ( J:173089 )
• in female germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
• oocytes contain fewer chiasmata than in wild-type cells
• however, oocytes exhibit normal nuclear envelop breakdown
abnormal spindle assembly in female meiosis ( J:173089 )
• chromosomes fail to align along abnormally long meiosis I spindle unlike in wild-type cells
abnormal male meiosis ( J:173089 )
• in male germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• autosomal synaptonemal-complex formation in spermatocytes and oocytes is never completed unlike in wild-type cells
abnormal male germ cell apoptosis ( J:173089 )
• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice
• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice
arrest of spermatogenesis ( J:173089 )
• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice
• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice

cellular
azoospermia ( J:173089 )
• male mice lack post-meiotic cells
abnormal chiasmata formation ( J:173089 )
• oocytes contain fewer chiasmata than wild-type cells
abnormal female meiosis ( J:173089 )
• in female germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
• oocytes contain fewer chiasmata than in wild-type cells
• however, oocytes exhibit normal nuclear envelop breakdown
abnormal spindle assembly in female meiosis ( J:173089 )
• chromosomes fail to align along abnormally long meiosis I spindle unlike in wild-type cells
abnormal male meiosis ( J:173089 )
• in male germ cells, autosomal synaptonemal-complex formation is never completed unlike in wild-type cells
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• autosomal synaptonemal-complex formation in spermatocytes and oocytes is never completed unlike in wild-type cells
abnormal male germ cell apoptosis ( J:173089 )
• spermatocytes are eliminated at a stage equivalent to mid-pachytene unlike in wild-type mice
• spermatocytes are eliminated in stage-IV tubules unlike in wild-type mice
abnormal double-strand DNA break repair ( J:173089 )
• spermatocytes and oocytes exhibit reduced steady-state numbers of single-stranded double-strand break repair (DSB) ends compared to wild-type cells

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:173089 )
• spermatocytes and oocytes exhibit reduced steady-state numbers of single-stranded double-strand break repair (DSB) ends compared to wild-type cells




Genotype
MGI:5013560
cx2
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1Atot/Hormad1tm1Atot
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
Hormad1tm1Atot mutation (0 available); any Hormad1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells




Genotype
MGI:5013559
cx3
Allelic
Composition		 Hormad1tm1Atot/Hormad1tm1Atot
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6JOlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hormad1tm1Atot mutation (0 available); any Hormad1 mutation (32 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173089 )
N
• unlike in Spo11tm1Sky homozygotes, oocyte numbers are normal
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
abnormal male meiosis ( J:173089 )
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• synaptonemal-complex defects are more severe than either single homozygote

cellular
abnormal female meiosis ( J:173089 )
• pseudo-sex-body-like formation is impaired compared to in wild-type cells
abnormal male meiosis ( J:173089 )
• sex-body formation is impaired compared to in wild-type cells
abnormal synaptonemal complex ( J:173089 )
• synaptonemal-complex defects are more severe than either single homozygote




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory