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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cop1tm2.1Vmd
targeted mutation 2.1, Vishva M Dixit
MGI:5013594
Summary 5 genotypes


Genotype
MGI:5013603
cn1
Allelic
Composition		 Cop1tm2.1Vmd/Cop1+
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 1 of 6 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 5 of 6 mice at 30 weeks of age

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 1 of 6 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 5 of 6 mice at 30 weeks of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 1 of 6 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 5 of 6 mice at 30 weeks of age




Genotype
MGI:5013604
cn2
Allelic
Composition		 Ptentm1Hwu/Ptentm1Hwu
Cop1tm2.1Vmd/Cop1tm2.1Vmd
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.CgCop1tm2.1Vmd Ptentm1Hwu Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Ptentm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age

reproductive system
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age

endocrine/exocrine glands
increased prostate gland adenocarcinoma incidence ( J:172653 )
• invasive in 11 of 13 mice at 30 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• high grade in 2 of 13 mice at 30 weeks of age




Genotype
MGI:5013605
cn3
Allelic
Composition		 Cop1tm2.1Vmd/Cop1tm2.1Vmd
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
prostate gland hyperplasia ( J:172653 )
• in 3 of 4 mice at 40 weeks of age
• in all mice at 52 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age
abnormal prostate gland physiology ( J:172653 )
• cells in the ventral and lateral prostate exhibit increased proliferation compared to in wild-type mice

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age

endocrine/exocrine glands
prostate gland hyperplasia ( J:172653 )
• in 3 of 4 mice at 40 weeks of age
• in all mice at 52 weeks of age
increased prostate intraepithelial neoplasia incidence ( J:172653 )
• low grade in 2 of 6 mice at 52 weeks of age
abnormal prostate gland physiology ( J:172653 )
• cells in the ventral and lateral prostate exhibit increased proliferation compared to in wild-type mice




Genotype
MGI:5013606
cn4
Allelic
Composition		 Cop1tm2.1Vmd/Cop1+
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 B6N.Cg-Cop1tm2.1Vmd Tg(Pbsn-cre)4Prb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
prostate gland hyperplasia ( J:172653 )
• in 1 of 7 mice at 52 weeks of age

endocrine/exocrine glands
prostate gland hyperplasia ( J:172653 )
• in 1 of 7 mice at 52 weeks of age




Genotype
MGI:5013602
cn5
Allelic
Composition		 Cop1tm1.1Vmd/Cop1tm2.1Vmd
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cop1tm1.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Cop1tm2.1Vmd mutation (0 available); any Cop1 mutation (44 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal prostate gland physiology ( J:172653 )
• xenografted prostate epithelium cells exhibit increased proliferation and form neoplastic prostate structures compared with xenografted wild-type cells

endocrine/exocrine glands
abnormal prostate gland physiology ( J:172653 )
• xenografted prostate epithelium cells exhibit increased proliferation and form neoplastic prostate structures compared with xenografted wild-type cells




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory