All Phenotypes Birc3<tm1.1Rbr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Birc3^tm1.1Rbr
targeted mutation 1.1, Robert Brink
MGI:5013655

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6 * NZB	MGI:5013717
cn2	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass	involves: 129P2/OlaHsd * C57BL/6 * NZB	MGI:5013718
cx3	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:5319381
cx4	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3^tm1Vmd	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL	MGI:5319384
cx5	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr	involves: 129S1/Sv * C57BL/6 * SJL	MGI:5319377
cx6	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319380
cx7	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL	MGI:5319385
cx8	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx	involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL	MGI:5319379
cx9	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: BALB/cJ * C57BL/6 * SJL	MGI:5319374
cx10	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx	involves: BALB/cJ * C57BL/6 * SJL	MGI:5319378
cx11	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: C57BL/6 * NZB	MGI:5013715
cx12	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr	involves: C57BL/6 * SJL	MGI:5319373

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

enlarged lymph nodes ( J:172843 )

hematopoietic system

decreased B cell apoptosis ( J:172843 )

enlarged spleen ( J:172843 )

decreased germinal center B cell number ( J:172843 )

• in response to CD40L, mice exhibit 10-fold lower germinal center B cells compared with wild-type mice

increased B cell number ( J:172843 )

• in the lymph nodes, follicular, and marginal zone

increased follicular B cell number ( J:172843 )

increased marginal zone B cell number ( J:172843 )

decreased spleen germinal center size ( J:172843 )

• in response to CD40L

cellular

decreased B cell apoptosis ( J:172843 )

growth/size/body

enlarged spleen ( J:172843 )

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Cd19^tm1(cre)Cgn/Cd19⁺ Tnfrsf13c^tm1Mass/Tnfrsf13c^tm1Mass
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * NZB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13c^tm1Mass homozygotes

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Ripk3^tm1Vmd mutation (1 available); any Ripk3 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• mice survive to E12.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk3^tm1Vmd/Ripk3^tm1Vmd
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice survive to E15.5

Allelic Composition	Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Xiap^tm1Vdr/Xiap^tm1Vdr
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Xiap^tm1Vdr mutation (0 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:182515 )

• mice are viable and fertile and have a normal phenotype

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1^tm1Led
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• mice survive to E12.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Ripk1^tm1Led/Ripk1⁺
Genetic Background	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Ripk1^tm1Led mutation (0 available); any Ripk1 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:182515 )

• mice survive to E15.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1b^tm1Imx/Tnfrsf1b^tm1Imx
Genetic Background	involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Tnfrsf1b^tm1Imx mutation (5 available); any Tnfrsf1b mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:182515 )

• around E10.5

cardiovascular system

abnormal heart atrium morphology ( J:182515 )

• sporadic discontinuities associated with pyknotic nuclei suggestive of apoptosis, usually in the atrial chamber

enlarged pericardium ( J:182515 )

• between E10.5 and E11.5, many mice exhibit swollen pericardial cavities filled with blood unlike in wild-type mice

hemorrhage ( J:182515 )

hemopericardium ( J:182515 )

• between E10.5 and E11.5

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

congestive heart failure ( J:182515 )

homeostasis/metabolism

hemopericardium ( J:182515 )

• between E10.5 and E11.5

muscle

decreased cardiac muscle contractility ( J:182515 )

• between E10.5 and E11.5, mice exhibit minimal or no contractile activity unlike in wild-type mice

Allelic Composition	Birc2^tm1.1Rbr/Birc2^tm1.1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr Tnfrsf1a^tm1Imx/Tnfrsf1a^tm1Imx
Genetic Background	involves: BALB/cJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc2^tm1.1Rbr mutation (0 available); any Birc2 mutation (33 available)
Birc3^tm1.1Rbr mutation (0 available); any Birc3 mutation (32 available)
Tnfrsf1a^tm1Imx mutation (6 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:182515 )

• while mice are born alive none survive to weaning

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: C57BL/6 * NZB

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:172843 )

N	• mice exhibit no differences in spleen or lymph node size or in the numbers or phenotype of the B cells within these peripheral lymphoid tissues compared with wild-type mice

Allelic Composition	Birc2^tm1Rbr/Birc2^tm1Rbr Birc3^tm1.1Rbr/Birc3^tm1.1Rbr
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:182515 )

• mice are viable with no reproductive or developmental defects

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