Phenotypes associated with this allele

• Allele Symbol: Ffar3^tm1Gzt
• Allele Name: targeted mutation 1, Gozoh Tsujimoto
• Allele ID: MGI:5013799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar3^tm1Gzt/Ffar3^tm1Gzt	involves: C57BL/6	MGI:5051648

Genotype
MGI:5051648

hm1

• Allelic Composition: Ffar3^tm1Gzt/Ffar3^tm1Gzt
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced sympathetic nerve activity in Ffar3^tm1Gzt/Ffar3^tm1Gzt mice

homeostasis/metabolism

increased circulating ketone body level ( J:172798 )

• beta-hydroxybutyrate plasma levels are increased compared to in wild-type mice

decreased body temperature ( J:172798 )

abnormal noradrenaline level ( J:172798 )

• cardiac noradrenaline is increased compared to in wild-type mice

• starved mice fail to exhibit an increase in heart noradrenaline levels compared with similarly treated wild-type mice

decreased circulating noradrenaline level ( J:172798 )

abnormal oxygen consumption ( J:172798 )

• treatment with propionate or beta-hydroxybutyrate, or tyramine fails to change oxygen consumption unlike in similarly treated wild-type mice

• during starvation, mice fail to exhibit a decrease in oxygen consumption unlike similarly treated wild-type mice

decreased oxygen consumption ( J:172798 )

• during feeding

decreased physiological sensitivity to xenobiotic ( J:172798 )

• sympathetic neurons fail to exhibit the propionate-activated response observed in wild-type mice

• isolated cardiomyocytes with sympathetic neurons fail to exhibit a rise in beat rate when treated with propionate compared with wild-type cells

• mice treated with beta-hydroxybutyrate or acetone exhibit less of a change in heart rate than in wild-type mice

• mice treated with streptozotocin to induce diabetes exhibit a reduced depression in heart rate compared with similarly treated wild-type mice

• whether diabetic or not, propranodol fails to affect heart rate unlike similarly treated wild-type mice

• treatment with propionate, beta-hydroxybutyrate, or tyramine fails to change oxygen consumption unlike in similarly treated wild-type mice

• however, mice treated with streptozotocin exhibit a diabetic condition

nervous system

small superior cervical ganglion ( J:172798 )

• at P1

abnormal sympathetic neuron innervation pattern ( J:172798 )

• mice exhibit reduced density of sympathetic innervations and TH in the heart compared with wild-type mice

abnormal sympathetic neuron physiology ( J:172798 )

• sympathetic neurons fail to exhibit the propionate-activated response observed in wild-type mice

• isolated cardiomyocytes with sympathetic neurons fail to exhibit a rise in beat rate when treated with propionate compared with wild-type cells

• mice fail to exhibit starvation-associated sympathetic depression unlike wild-type mice

cardiovascular system

abnormal heart rate ( J:172798 )

• fasted mice fail to exhibit as much of a decrease in heart rate as in wild-type mice

• mice treated with propionate or octanoate fail to exhibit a change in heart rate unlike similarly treated wild-type mice

• isolated cardiomyocytes with sympathetic neurons fail to exhibit a rise in beat rate when treated with propionate compared with wild-type cells

• mice treated with beta-hydroxybutyrate or acetone exhibit less of a change in heart rate than in wild-type mice

• mice treated with streptozotocin to induce diabetes exhibit a reduced depression in heart rate compared with similarly treated wild-type mice

• whether diabetic or not, propranodol fails to affect heart rate unlike similarly treated wild-type mice

decreased heart rate ( J:172798 )

• in resting mice