About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp4tm1Xilu
targeted mutation 1, Xiongbin Lu
MGI:5013819
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp4tm1Xilu/Usp4tm1Xilu B6.129-Usp4tm1Xilu MGI:5013824


Genotype
MGI:5013824
hm1
Allelic
Composition		 Usp4tm1Xilu/Usp4tm1Xilu
Genetic
Background		 B6.129-Usp4tm1Xilu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp4tm1Xilu mutation (0 available); any Usp4 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:173192 )
• mouse embryonic fibroblasts (MEFs) exhibit growth retardation and resistance against oncogenic transformation compared with wild-type cells
increased cellular sensitivity to ionizing radiation ( J:173192 )
• in mouse embryonic fibroblasts
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation
early cellular replicative senescence ( J:173192 )
• in mouse embryonic fibroblasts

hematopoietic system
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation

immune system
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation
increased splenocyte apoptosis ( J:173192 )
• induced by irradiation

endocrine/exocrine glands
increased thymocyte apoptosis ( J:173192 )
• induced by irradiation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory