All Phenotypes Clec4e<tm1Tks> MGI Mouse

decreased susceptibility to xenobiotic induced morbidity/mortality ( J:203159 )

• in mice treated with oil-in-water emulsion of trehalose-6,60'-dimycolate (TDM)

decreased dendritic cell number ( J:203159 )

• TDM-treated mice exhibit less of an increase in draining lymph nodes dendritic cells compared with wild-type mice

decreased susceptibility to type IV hypersensitivity reaction ( J:203159 )

• TDM-treated mice immunized with ovalbumin exhibit reduced footpad swelling and anti-ovalbumin IgG compared with wild-type mice

abnormal immune serum protein physiology ( J:203159 )

decreased IgG level ( J:203159 )

• in TDM-treated mice immunized with ovalbumin

decreased circulating interleukin-17 level ( J:203159 )

• in mice re-challenged with MOG antigen and pertussis toxin 20 days after immunization for EAE

abnormal chemokine secretion ( J:203159 )

• bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in trehalose-6,60'-dimycolate (TDM) or zymosan exhibit reduced MIP-2 secretion compared with wild-type cells

abnormal interferon-gamma secretion ( J:203159 )

• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 or OVA257-264 peptide or ovalbumin protein fail to exhibit an increase in IFN-gamma and IL17 unlike wild-type cells

abnormal interleukin-17 secretion ( J:203159 )

• TDM-treated bone marrow dendritic cells co-cultured with OT-II cells and OVA323-339 peptide fail to exhibit an increase in IFN-gamma and IL17 unlike wild-type cells

decreased tumor necrosis factor secretion ( J:203159 )

• in bone marrow-derived dendritic cells and macrophages stimulated with platelets coated in TDM or zymosan

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:203159 )

• without skin inflammation in TDM-treated mice

abnormal response to infection ( J:203159 )

• mice infected with Mycobacterium bovis BCG exhibit reduced IFN-gamma production in response to PPD compared with wild-type mice