Phenotypes associated with this allele

• Allele Symbol: Pinx1^tm1.1Kplu
• Allele Name: targeted mutation 1.1, Kun Ping Lu
• Allele ID: MGI:5013947
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pinx1^tm1.1Kplu/Pinx1^tm1.1Kplu	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5013959
ht2	Pinx1^tm1.1Kplu/Pinx1^+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5013958
cx3	Pinx1^tm1.1Kplu/Pinx1^+ Tert^tm1Leah/Tert^tm1Leah	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5300686
cx4	Pinx1^tm1.1Kplu/Pinx1^+ Trp53^tm1Brd/Trp53^+	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5013960
cx5	Pinx1^tm1.1Kplu/Pinx1^+ Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5013961

Genotype
MGI:5013959

hm1

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1^tm1.1Kplu
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Pinx1^tm1.1Kplu/Pinx1^tm1.1Kplu mice are embryonic lethal

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:171997 )

• no mice are present at E10.5 and E12.5

embryo

decreased embryo size ( J:171997 )

• at E9.5 and E10.5

hematopoietic system

anemia ( J:171997 )

• at E9.5 and E10.5, mice are very pale and appear devoid of a blood supply compared with wild-type mice

cardiovascular system

absent heartbeat ( J:171997 )

• at E9.5 and E10.5

growth/size/body

decreased embryo size ( J:171997 )

• at E9.5 and E10.5

integument

pallor ( J:171997 )

• very pale at E9.5 and E10.5

Genotype
MGI:5013958

ht2

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Varied histopathology of Pinx1^tm1.1Kplu/Pinx1⁺ tumors

mortality/aging

prenatal lethality, incomplete penetrance ( J:171997 )

• some mice die in utero

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:171997 )

• 10% of tumors in the stomach, small intestine, colon, and rectum

neoplasm

increased tumor incidence ( J:171997 )

• 49 of 52 mice between 9 and 18 months of age develop tumors (lung cancer, liver cancer, mammary cancer, and gastrointestinal tract tumors)

• tumors exhibit nuclear atypia, desmoplasia, stromal invasion, and/or distant metastasis

• mice develop lung metastasis from lung cancer or mammary cancer

• tumors exhibit telomere elongation, anaphase bridges, and/or lagging chromosomes

increased gastrointestinal tumor incidence ( J:171997 )

• 10% of tumors in the stomach, small intestine, colon, and rectum

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

increased Harderian gland adenoma incidence ( J:171997 )

• 3% of tumors are eye Harderian gland adenoma

increased liver tumor incidence ( J:171997 )

• 18% of tumors

increased hibernoma incidence ( J:171997 )

• 2% of tumors

increased lymphoma incidence ( J:171997 )

• 7% of tumors

increased histiocytic sarcoma incidence ( J:171997 )

• 3% of tumors

increased carcinoma incidence ( J:171997 )

• 2% of tumors are leiomyocarcinoma

increased sarcoma incidence ( J:171997 )

• 2% of tumors are undifferentiated sarcoma

increased hemangiosarcoma incidence ( J:171997 )

• 2% of tumors

increased lung tumor incidence ( J:171997 )

• 37% of tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

increased Harderian gland adenoma incidence ( J:171997 )

• 3% of tumors are eye Harderian gland adenoma

liver/biliary system

increased liver tumor incidence ( J:171997 )

• 18% of tumors

cellular

increased telomere length ( J:171997 )

• elongated in tumor cells

chromosomal instability ( J:171997 )

• tumors exhibit anaphase bridges and/or lagging chromosomes, indicating chromosome instability

respiratory system

increased lung tumor incidence ( J:171997 )

• 37% of tumors

integument

increased mammary gland tumor incidence ( J:171997 )

• 13% of tumors

skin hyperplasia ( J:171997 )

• 3% of tumors

Genotype
MGI:5300686

cx3

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1⁺; Tert^tm1Leah/Tert^tm1Leah
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N

Telomere elongation and anaphase bridges are prevented in Pinx1^tm1.1Kplu/Pinx1⁺ Tert^tm1Leah/Tert^tm1Leah mice

cellular

cellular phenotype ( J:171997 )

N • double mutants do not exhibit the telomere lengthening, anaphase bridges, lagging chromosomes or aneuploidy that is seen in single Pinx1 heterozygotes

Genotype
MGI:5013960

cx4

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1⁺; Trp53^tm1Brd/Trp53⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

mortality/aging

premature death ( J:171997 )

• mice die between 9 and 12 months

neoplasm

increased tumor incidence ( J:171997 )

• mice develop epithelial carcinomas such as lung, liver, breast, and gastrointestinal cancers

increased mammary gland tumor incidence ( J:171997 )

• 18% of tumors

increased ovary tumor incidence ( J:171997 )

♀ • 9% of tumors

increased liver tumor incidence ( J:171997 )

• 27% of tumors

increased hepatocellular carcinoma incidence ( J:171997 )

increased lymphoma incidence ( J:171997 )

• 27% of tumors

increased carcinoma incidence ( J:171997 )

• mice develop epithelial carcinomas such as lung, liver, breast, and gastrointestinal cancers

increased lung tumor incidence ( J:171997 )

increased lung carcinoma incidence ( J:171997 )

liver/biliary system

increased liver tumor incidence ( J:171997 )

• 27% of tumors

increased hepatocellular carcinoma incidence ( J:171997 )

respiratory system

increased lung tumor incidence ( J:171997 )

increased lung carcinoma incidence ( J:171997 )

reproductive system

increased ovary tumor incidence ( J:171997 )

♀ • 9% of tumors

integument

increased mammary gland tumor incidence ( J:171997 )

• 18% of tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:171997 )

• 18% of tumors

increased ovary tumor incidence ( J:171997 )

♀ • 9% of tumors

Genotype
MGI:5013961

cx5

• Allelic Composition: Pinx1^tm1.1Kplu/Pinx1⁺; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

mortality/aging

premature death ( J:171997 )

• mice die between 6 and 9 months

neoplasm

increased gastrointestinal tumor incidence ( J:171997 )

• 11% of tumors

increased mammary gland tumor incidence ( J:171997 )

• 11% of tumors

increased liver tumor incidence ( J:171997 )

• 33% of tumors

increased hepatocellular carcinoma incidence ( J:171997 )

increased lymphoma incidence ( J:171997 )

• 44% of tumors

increased carcinoma incidence ( J:171997 )

• mice develop epithelial carcinomas such as lung, liver, breast, and gastrointestinal cancers

increased lung carcinoma incidence ( J:171997 )

liver/biliary system

increased liver tumor incidence ( J:171997 )

• 33% of tumors

increased hepatocellular carcinoma incidence ( J:171997 )

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:171997 )

• 11% of tumors

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:171997 )

• 11% of tumors

integument

increased mammary gland tumor incidence ( J:171997 )

• 11% of tumors

respiratory system

increased lung carcinoma incidence ( J:171997 )