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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mir21atm1Yoli
targeted mutation 1, Yong Li
MGI:5014257
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mir21atm1Yoli/Mir21atm1Yoli involves: 129S6/SvEvTac * C57BL/6N MGI:5014258


Genotype
MGI:5014258
hm1
Allelic
Composition
Mir21atm1Yoli/Mir21atm1Yoli
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir21atm1Yoli mutation (2 available); any Mir21a mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• treatment with a skin carcinogenesis (DMBA/TPA) protocol results in a small but significant decrease in proliferating cell numbers compared to similarly treated control mice
• decrease in the incidence of papillomas in a skin carcinogenesis assay

neoplasm
• decrease in the incidence of papillomas in a skin carcinogenesis assay
• papillomas that do form following a skin carcinogenesis (DMBA/TPA) protocol contain more apoptotic cells

integument
• increase in the number of apoptotic cells in the epidermis in the presence or absence of TPA treatment
• enhanced keratinocyte apoptosis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory