homeostasis/metabolism
• treatment with a skin carcinogenesis (DMBA/TPA) protocol results in a small but significant decrease in proliferating cell numbers compared to similarly treated control mice
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• decrease in the incidence of papillomas in a skin carcinogenesis assay
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neoplasm
• decrease in the incidence of papillomas in a skin carcinogenesis assay
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• papillomas that do form following a skin carcinogenesis (DMBA/TPA) protocol contain more apoptotic cells
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integument
• increase in the number of apoptotic cells in the epidermis in the presence or absence of TPA treatment
• enhanced keratinocyte apoptosis
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