Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-Fig4*I41T)721Mm
• Allele Name: transgene insertion 721, Miriam H Meisler
• Allele ID: MGI:5014489
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fig4^plt1/Fig4^plt1 Tg(ACTB-Fig4*I41T)721Mm/0	involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL	MGI:5014492

Genotype
MGI:5014492

cx1

• Allelic Composition: Fig4^plt1/Fig4^plt1; Tg(ACTB-Fig4*I41T)721Mm/0
• Genetic Background: involves: 129 * C3H * C57BL/6J * CAST/Ei * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:173446 )

N • survival is completely corrected compared to Fig4 null mice not carrying the transgene

nervous system

nervous system phenotype ( J:173446 )

N • unlike in null mice not carrying the transgene, myelin sheath thinning is not seen

abnormal brain morphology ( J:173446 )

• a few autophagic inclusion bodies are present

hydrocephaly ( J:173446 )

enlarged lateral ventricles ( J:173446 )

astrocytosis ( J:173446 )

• astrocytosis is almost completely corrected compared to null mice not carrying the transgene

neurodegeneration ( J:173446 )

• minimal spongiform degeneration unlike in null mice not carrying the transgene

• unlike in null mice not carrying the transgene, dorsal root ganglia are intact at P90

• degeneration of the cerebellar nuclei

spongiform encephalopathy ( J:173446 )

• minimal

decreased nerve conduction velocity ( J:173446 )

• reduced at 4 and 14 months of age in the sciatic nerve but not as much as in null mice not carrying the transgene

pigmentation

hypopigmentation ( J:173446 )

• partial rescue of reduced pigmentation compared to null mice not carrying the transgene