Phenotypes associated with this allele

• Allele Symbol: Pth1r^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5014612
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pth1r^tm1a(EUCOMM)Hmgu/Pth1r^tm1a(EUCOMM)Hmgu	C57BL/6N-Pth1r^tm1a(EUCOMM)Hmgu/Wtsi	MGI:5631451
ht2	Pth1r^tm1a(EUCOMM)Hmgu/Pth1r^+	C57BL/6N-Pth1r^tm1a(EUCOMM)Hmgu/Wtsi	MGI:5706071

Genotype
MGI:5631451

hm1

• Allelic Composition: Pth1r^{tm1a(EUCOMM)Hmgu}/Pth1r^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Pth1r^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0733_7_D02

Data Sources

IMPC Data for Pth1r

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

abnormal vertebral artery topology ( J:239583 )

DMDD

abnormal ductus venosus valve morphology ( J:239583 )

DMDD

absent ductus venosus valve ( J:239583 )

DMDD

jugular vein stenosis ( J:239583 )

DMDD

enlarged paraumbilical vein ( J:239583 )

DMDD

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

placenta hemorrhage ( J:239583 , J:261316 )

DMDD (J:239583)

MGI

• hemorrhagic areas/blood pools are seen in the E14.5 placenta (J:261316)

embryo

placenta hemorrhage ( J:239583 , J:261316 )

DMDD (J:239583)

MGI

• hemorrhagic areas/blood pools are seen in the E14.5 placenta (J:261316)

abnormal placenta morphology ( J:261316 )

• abnormal spongiotrophoblast inclusions in the placenta at E14.5

• distorted spongiotrophoblast/labyrinth ratio at E14.5

endocrine/exocrine glands

dilated bile duct ( J:239583 )

DMDD

abnormal thymus morphology ( J:239583 )

DMDD

hematopoietic system

abnormal thymus morphology ( J:239583 )

DMDD

homeostasis/metabolism

retropharyngeal edema ( J:239583 )

DMDD

immune system

abnormal thymus morphology ( J:239583 )

DMDD

enlarged lymphatic vessel ( J:239583 )

DMDD

blood in lymph vessels ( J:239583 )

DMDD

liver/biliary system

dilated bile duct ( J:239583 )

DMDD

herniated liver ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 , J:261316 )

IMPC - WTSI (J:211773)

MGI

• lethality at P14, with viable fetuses at E14.5 (J:261316)

neoplasm

increased hemangioma incidence ( J:239583 )

DMDD

nervous system

abnormal brain morphology ( J:239583 )

DMDD

anastomosis between internal carotid artery and basilar artery ( J:239583 )

DMDD

absent segment of posterior cerebral artery ( J:239583 )

DMDD

vision/eye

abnormal lens morphology ( J:239583 )

DMDD

decreased total retina thickness ( J:239583 )

DMDD

Genotype
MGI:5706071

ht2

• Allelic Composition: Pth1r^{tm1a(EUCOMM)Hmgu}/Pth1r⁺
• Genetic Background: C57BL/6N-Pth1r^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0733_7_D02

Data Sources

IMPC Data for Pth1r

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - WTSI

behavior/neurological

increased grip strength ( J:211773 )

IMPC - WTSI

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - WTSI

skeleton

decreased bone mineral content ( J:211773 )

♀

IMPC - WTSI