Analysis Tools|
Allele Symbol Allele Name Allele ID |
Zfp871tm1a(EUCOMM)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:5014690 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the single viable pup was less than half the size of littermates
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• the single viable pup survived for 17 days
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• out of 52 pups from 10 litters only a single homozygous pup was born alive
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no incidence of T-cell lymphoma compared to 3.7% in wild-type mice
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• slightly increased,16.7% incidence compared to 11.8% in wild-type mice
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• steatohepatitis in 50% of mice compared to 6% in wild-type mice
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• steatohepatitis in 50% of mice compared to 6% in wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• splenic/thymic hyperplasia in 96% of mice compared to 3.9% of wild-type mice
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• steatohepatitis in 50% of mice compared to 6% in wild-type mice
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• median survival time (89.3 weeks) is decreased compared to wild-type controls (117 weeks)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pups are about half the size of heterozygous littermates
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• 3 pups were born alive, out of 33 pups in seven litters, but two died 1 day after birth and the third died at P24
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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