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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc25a37tm1.1Kapl
targeted mutation 1.1, Jerry Kaplan
MGI:5014803
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Tg(Mx1-cre)1Cgn/? 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA MGI:5014819
cn2
 		Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/? 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA MGI:5014820
cn3
 		Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Tg(Tek-cre)1Ywa/? 		involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * SJL MGI:5014818
cn4
 		Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA MGI:6514398
cn5
 		Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA MGI:6514411
cn6
 		Slc25a28tm1.1Dwrd/Slc25a28tm1.1Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA MGI:6514413


Genotype
MGI:5014819
cn1
Allelic
Composition		 Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Slc25a37tm1.2Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal definitive hematopoiesis ( J:173284 )
• increased in the spleen in mice treated with poly (I:C)
abnormal erythropoiesis ( J:173284 )
• ineffective erythropoiesis in bone marrow and spleen in mice treated with poly (I:C)
anemia ( J:173284 )
• development of anemia in mice treated with poly (I:C)
increased erythroid progenitor cell number ( J:173284 )
• 5 fold increase in splenic erythroid progenitor cells in mice treated with poly (I:C)
• 10 fold increase in primitive erythroid progenitor cells in bone marrow
• increased number of non-viable cells in both spleen and bone marrow
increased erythroblast number ( J:173284 )
• 2 fold increase in bone marrow in mice treated with poly (I:C)
decreased erythrocyte cell number ( J:173284 )
• decreased red blood cell number in mice treated with poly (I:C)
• 50% decrease in mature red blood cell numbers in bone marrow
decreased hematocrit ( J:173284 )
• in mice treated with poly (I:C)
decreased hemoglobin content ( J:173284 )
• in mice treated with poly (I:C)
decreased mean corpuscular volume ( J:173284 )
• in mice treated with poly (I:C)
abnormal B cell morphology ( J:173284 )
• 6 fold decrease in cell number in mice treated with poly (I:C)
• four fold decrease in B cell lineage cells in bone marrow
abnormal T cell morphology ( J:173284 )
• 4 fold decrease in cell number mice treated with poly (I:C)
abnormal spleen morphology ( J:173284 )
• changes in spleen architecture in mice treated with poly (I:C)
enlarged spleen ( J:173284 )
• in mice treated with poly (I:C)

immune system
abnormal B cell morphology ( J:173284 )
• 6 fold decrease in cell number in mice treated with poly (I:C)
• four fold decrease in B cell lineage cells in bone marrow
abnormal T cell morphology ( J:173284 )
• 4 fold decrease in cell number mice treated with poly (I:C)
abnormal spleen morphology ( J:173284 )
• changes in spleen architecture in mice treated with poly (I:C)
enlarged spleen ( J:173284 )
• in mice treated with poly (I:C)

growth/size/body
enlarged spleen ( J:173284 )
• in mice treated with poly (I:C)




Genotype
MGI:5014820
cn2
Allelic
Composition		 Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Slc25a37tm1.2Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:173284 )
N
• viability is normal

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:173284 )
N
• iron and heme metabolism is normal unless fed delta aminolevulinic acid
abnormal iron homeostasis ( J:173284 )
• increased protoporphyrin IX in liver, plasma, and red blood cells when fed delta aminolevulinic acid

liver/biliary system
enlarged liver ( J:173284 )
• when fed delta aminolevulinic acid
liver fibrosis ( J:173284 )
• increased collagen deposition when fed delta aminolevulinic acid, also occurs to a to lesser extent in heterozygotes
cholestasis ( J:173284 )
• bile accumulation occurs when fed delta aminolevulinic acid

hematopoietic system
enlarged spleen ( J:173284 )
• slightly enlarged when fed delta aminolevulinic acid

immune system
enlarged spleen ( J:173284 )
• slightly enlarged when fed delta aminolevulinic acid

growth/size/body
enlarged liver ( J:173284 )
• when fed delta aminolevulinic acid
enlarged spleen ( J:173284 )
• slightly enlarged when fed delta aminolevulinic acid




Genotype
MGI:5014818
cn3
Allelic
Composition		 Slc25a37tm1.1Kapl/Slc25a37tm1.2Kapl
Tg(Tek-cre)1Ywa/?
Genetic
Background		 involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Slc25a37tm1.2Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:173284 )
• no live mice can be identified




Genotype
MGI:6514398
cn4
Allelic
Composition		 Slc25a28tm1.2Dwrd/Slc25a28tm1.2Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a28tm1.2Dwrd mutation (0 available); any Slc25a28 mutation (18 available)
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
impaired liver regeneration ( J:300667 )
• reduced liver cell proliferation 48h after partial hepatectomy

cellular
abnormal oxidative phosphorylation ( J:300667 )
• significant reduction in OXPHOS protein levels in liver

embryo
embryo phenotype ( J:300667 )
N
• mice born at expected Mendelian ratio




Genotype
MGI:6514411
cn5
Allelic
Composition		 Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron or regular chow
• reduced nonheme iron level in liver when fed low-iron chow
impaired liver regeneration ( J:300667 )
• reduced liver cell proliferation 48h after partial hepatectomy

homeostasis/metabolism
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron or regular chow
• reduced nonheme iron level in liver when fed low-iron chow

cellular
abnormal oxidative phosphorylation ( J:300667 )
• significant reduction in OXPHOS protein levels in liver




Genotype
MGI:6514413
cn6
Allelic
Composition		 Slc25a28tm1.1Dwrd/Slc25a28tm1.1Dwrd
Slc25a37tm1.1Kapl/Slc25a37tm1.1Kapl
Speer6-ps1Tg(Alb-cre)21Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc25a28tm1.1Dwrd mutation (0 available); any Slc25a28 mutation (18 available)
Slc25a37tm1.1Kapl mutation (0 available); any Slc25a37 mutation (9 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron or regular chow
• reduced nonheme iron level in liver when fed low-iron chow

liver/biliary system
decreased liver iron level ( J:300667 )
• reduced nonheme iron level in liver mitochondria when fed low-iron or regular chow
• reduced nonheme iron level in liver when fed low-iron chow




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory