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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock2m2Btlr
mutation 2, Bruce Beutler
MGI:5049870
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock2m2Btlr/Dock2m2Btlr C57BL/6J-Dock2m2Btlr MGI:5049880
hm2
 		Dock2m2Btlr/Dock2m2Btlr involves: C57BL/6J MGI:5429187


Genotype
MGI:5049880
hm1
Allelic
Composition		 Dock2m2Btlr/Dock2m2Btlr
Genetic
Background		 C57BL/6J-Dock2m2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m2Btlr mutation (1 available); any Dock2 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:173670 )
• mice exhibit reduced B220+ cells compared with wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:173670 )
• reduced frequencu in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:173670 )
• reduced frequencu in the periphery
abnormal humoral immune response ( J:173670 )
• mice lack a T-dependent IgG response to model antigens encoded by a recombinant nonreplicating Semliki Forest Virus vector unlike wild-type mice
• however, T-independent IgM responses to NP-Ficoll are normal

hematopoietic system
decreased B cell number ( J:173670 )
• mice exhibit reduced B220+ cells compared with wild-type mice
decreased CD4-positive, alpha-beta T cell number ( J:173670 )
• reduced frequencu in the periphery
decreased CD8-positive, alpha-beta T cell number ( J:173670 )
• reduced frequencu in the periphery




Genotype
MGI:5429187
hm2
Allelic
Composition		 Dock2m2Btlr/Dock2m2Btlr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m2Btlr mutation (1 available); any Dock2 mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:185495 )
N
• mice exhibit a normal response to NP-Ficoll
abnormal B cell differentiation ( J:185495 )
• flow cytometry analysis of blood revealed low expression of B220 suggesting a block in B cell maturation compared with wild-type mice
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
abnormal humoral immune response ( J:185495 )
• mice lack a T-dependent IgG response to model antigens encoded by a recombinant nonreplicating Semliki Forest Virus vector compared with wild-type mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

hematopoietic system
abnormal B cell differentiation ( J:185495 )
• flow cytometry analysis of blood revealed low expression of B220 suggesting a block in B cell maturation compared with wild-type mice
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased T cell number ( J:185495 )
• T cell deficiency
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory