Phenotypes associated with this allele

• Allele Symbol: Msx1^{tm2.1(cre/ERT2)Bero}
• Allele Name: targeted mutation 2.1, Benoit Robert
• Allele ID: MGI:5049923
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Msx1^tm2.1(cre/ERT2)Bero/Msx1^tm1Bero	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5473567
cn2	Msx1^tm1Bero/Msx1^tm2.1(cre/ERT2)Bero Msx2^tm1Yvla/Msx2^tm1Yvla	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI	MGI:5297713
cx3	Msx1^tm2.1(cre/ERT2)Bero/Msx1^tm2.1(cre/ERT2)Bero Msx2^tm1Bero/Msx2^tm1Bero	involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:5473569

Genotype
MGI:5473567

ht1

• Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^tm1Bero
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal embryonic tissue morphology ( J:194129 )

• internal organ development is disrupted due to thoracoabdominoschisis

growth/size/body

abnormal facial morphology ( J:194129 )

• at E12.5, embryos have highly deformed faces

thoracoabdominoschisis ( J:194129 )

• at E12.3 embryos show thoracoabdominoschisis (opening of both the thorax and abdomen)

craniofacial

abnormal facial morphology ( J:194129 )

• at E12.5, embryos have highly deformed faces

nervous system

exencephaly ( J:194129 )

• at E12.5

liver/biliary system

abnormal liver development ( J:194129 )

• liver appears rudimentary

vision/eye

abnormal eye morphology ( J:194129 )

• embryos display atrophic eyes at E12.5

Genotype
MGI:5297713

cn2

• Allelic Composition: Msx1^tm1Bero/Msx1^{tm2.1(cre/ERT2)Bero}; Msx2^tm1Yvla/Msx2^tm1Yvla
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * NMRI

cardiovascular system

abnormal carotid artery morphology ( J:173525 )

• increased carotid artery vessel diameter is observed

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

muscle

vascular smooth muscle hypoplasia ( J:173525 )

• a reduction in vascular smooth muscle cell (VSMC) coverage (depletion of mural cells) is observed

Genotype
MGI:5473569

cx3

• Allelic Composition: Msx1^{tm2.1(cre/ERT2)Bero}/Msx1^{tm2.1(cre/ERT2)Bero}; Msx2^tm1Bero/Msx2^tm1Bero
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

mortality/aging

neonatal lethality ( J:194129 )

• animals die during first day following birth likely from denutrition, dehydration or hypothermia

craniofacial

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

absent malleus processus brevis ( J:194129 )

• observed at autopsy

cleft secondary palate ( J:194129 )

• observed at autopsy

skeleton

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

absent malleus processus brevis ( J:194129 )

• observed at autopsy

digestive/alimentary system

cleft secondary palate ( J:194129 )

• observed at autopsy

hearing/vestibular/ear

absent malleus processus brevis ( J:194129 )

• observed at autopsy

behavior/neurological

absent gastric milk in neonates ( J:194129 )

• newborns have no milk in their stomach, suggesting denutrition/dehydration might be cause of lethality

growth/size/body

absent teeth ( J:194129 )

• general tooth agenesis observed at autopsy

cleft secondary palate ( J:194129 )

• observed at autopsy