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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adh5tm1.1Llli
targeted mutation 1.1, Limin Liu
MGI:5049924
Summary 2 genotypes


Genotype
MGI:5049928
cn1
Allelic
Composition		 Adh5tm1.1Llli/Adh5tm1.1Llli
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 B6.Cg-Adh5tm1.1Llli Commd10Tg(Vav1-icre)A2Kio
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1.1Llli mutation (0 available); any Adh5 mutation (28 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:173666 )
N
• mice exhibit normal survival following diethylnitrosamine (DEN) challenged




Genotype
MGI:5049927
cn2
Allelic
Composition		 Adh5tm1.1Llli/Adh5tm1.1Llli
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 B6.Cg-Adh5tm1.1Llli Speer6-ps1Tg(Alb-cre)21Mgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adh5tm1.1Llli mutation (0 available); any Adh5 mutation (28 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173666 )
• diethylnitrosamine (DEN)-challenged mice exhibit decreased survival compared with similarly treated wild-type mice
increased susceptibility to bacterial infection induced morbidity/mortality ( J:173666 )
• LPS-challenged mice exhibit decreased survival compared with similarly treated wild-type mice

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:173666 )
• diethylnitrosamine (DEN)-challenged mice exhibit decreased survival compared with similarly treated wild-type mice

immune system
increased susceptibility to bacterial infection induced morbidity/mortality ( J:173666 )
• LPS-challenged mice exhibit decreased survival compared with similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/21/2024
MGI 6.24 		The Jackson Laboratory