All Phenotypes Tsx<tm1.2Jtl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsx^tm1.2Jtl/Tsx^tm1.2Jtl	B6.129S(FVB)-Tsx^tm1.2Jtl	MGI:5293827
ot2	Tsx^tm1.2Jtl/Y	B6.129S(FVB)-Tsx^tm1.2Jtl	MGI:5293826

Allelic Composition	Tsx^tm1.2Jtl/Tsx^tm1.2Jtl
Genetic Background	B6.129S(FVB)-Tsx^tm1.2Jtl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsx^tm1.2Jtl mutation (1 available); any Tsx mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced female fertility ( J:177104 )

decreased litter size ( J:177104 )

• homozygous females mated to hemizygous males or wild-type males produce smaller litters and litter ratios indicate a slight increase in female births

• litters produced using hemizygous males crossed to wild-type females are similar to controls

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced contextual conditioning behavior ( J:177104 )

• short-term contextual conditioning behavior (1 hour retention interval) as measured by the fear conditioning test is improved as compared to wild-type

• higher levels of freezing in the fear conditioning test are observed only in males

endocrine/exocrine glands

small testis ( J:177104 )

testis hypoplasia ( J:177104 )

• germ cell apoptosis is significantly increased at 7 days, 14 days and 2 months, however, by 1 year apoptosis levels do not differ from wild-type

• apoptosis is greatest at 14 days (5X higher than controls) during meiotic prophase I

• TUNEL staining indicates that a subset of pachytene-stage spermatocytes inappropriately undergo apoptosis