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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nat10tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:5050156
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nat10tm1a(KOMP)Wtsi/Nat10tm1a(KOMP)Wtsi C57BL/6NTac-Nat10tm1a(KOMP)Wtsi MGI:7311566
ht2
 		Nat10tm1a(KOMP)Wtsi/Nat10+ C57BL/6NTac-Nat10tm1a(KOMP)Wtsi MGI:7311568
cx3
 		Lmnatm1.1Otin/Lmnatm1.1Otin
Nat10tm1a(KOMP)Wtsi/Nat10+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7311572
cx4
 		Lmnatm1.1Otin/Lmna+
Nat10tm1a(KOMP)Wtsi/Nat10+ 		involves: 129P2/OlaHsd * C57BL/6NTac MGI:7311574


Genotype
MGI:7311566
hm1
Allelic
Composition		 Nat10tm1a(KOMP)Wtsi/Nat10tm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6NTac-Nat10tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nat10tm1a(KOMP)Wtsi mutation (2 available); any Nat10 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7311568
ht2
Allelic
Composition		 Nat10tm1a(KOMP)Wtsi/Nat10+
Genetic
Background		 C57BL/6NTac-Nat10tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nat10tm1a(KOMP)Wtsi mutation (2 available); any Nat10 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:261974 )




Genotype
MGI:7311572
cx3
Allelic
Composition		 Lmnatm1.1Otin/Lmnatm1.1Otin
Nat10tm1a(KOMP)Wtsi/Nat10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Otin mutation (0 available); any Lmna mutation (83 available)
Nat10tm1a(KOMP)Wtsi mutation (2 available); any Nat10 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:261974 )
• delayed compared to mice homozygous for the Lmnatm1.1Otin and wild-type Nat10

reproductive system
reproductive system phenotype ( J:261974 )
N
• unlike mice homozygous for the Lmnatm1.1Otin, mice do not exhibit penis prolapse
reduced fertility ( J:261974 )
• partially rescued compared to mice homozygous for the Lmnatm1.1Otin and wild-type Nat10

skeleton
kyphosis ( J:261974 )
• delayed compared to mice homozygous for the Lmnatm1.1Otin and wild-type Nat10

vision/eye
vision/eye phenotype ( J:261974 )
N
• unlike mice homozygous for the Lmnatm1.1Otin, mice do not exhibit keratoconjunctivitis sicca

cardiovascular system
decreased heart rate ( J:261974 )
• delayed onset

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
 J:261974




Genotype
MGI:7311574
cx4
Allelic
Composition		 Lmnatm1.1Otin/Lmna+
Nat10tm1a(KOMP)Wtsi/Nat10+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1.1Otin mutation (0 available); any Lmna mutation (83 available)
Nat10tm1a(KOMP)Wtsi mutation (2 available); any Nat10 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

skeleton
kyphosis ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

growth/size/body
decreased body weight ( J:261974 )
• significantly delayed compared to in Lmnatm1.1Otin homozygotes

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
 J:261974




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory