All Phenotypes Mitf<tm5.1Arnh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mitf^tm5.1Arnh
targeted mutation 5.1, Heinz Arnheiter
MGI:5050703

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316607
ht2	Mitf^tm5.1Arnh/Mitf^Mi-wh	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA	MGI:5316609
cx3	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh Kit^tm1Alf/Kit⁺	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N	MGI:5316641

Allelic Composition	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^tm5.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:182722 )

N	• normal pigmentation

Allelic Composition	Mitf^tm5.1Arnh/Mitf^Mi-wh
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (74 available)
Mitf^tm5.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

darkened coat color ( J:182722 )

• considerably darkened compared to heterozygous Mitf^Mi-wh/Mitf⁺ mice

belly spot ( J:182722 )

pigmentation

darkened coat color ( J:182722 )

• considerably darkened compared to heterozygous Mitf^Mi-wh/Mitf⁺ mice

belly spot ( J:182722 )

Allelic Composition	Mitf^tm5.1Arnh/Mitf^tm5.1Arnh Kit^tm1Alf/Kit⁺
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kit^tm1Alf mutation (1 available); any Kit mutation (182 available)
Mitf^tm5.1Arnh mutation (0 available); any Mitf mutation (74 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal coat/hair pigmentation ( J:182722 )

belly spot ( J:182722 )

• slightly larger belly spots

abnormal melanocyte morphology ( J:182722 )

• more melanocytes around the eyes at E15.5 and at birth compared to controls involving Mitf^tm7.1Arnh

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

integument

abnormal coat/hair pigmentation ( J:182722 )

abnormal hair follicle melanocyte morphology ( J:182722 )

• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitf^tm7.1Arnh

belly spot ( J:182722 )

• slightly larger belly spots

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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