Phenotypes associated with this allele

• Allele Symbol: Inpp5d^el20
• Allele Name: early lethal
• Allele ID: MGI:5050823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Inpp5d^el20/Inpp5d^el20	B6.129-Inpp5d^el20	MGI:5050835

Genotype
MGI:5050835

hm1

• Allelic Composition: Inpp5d^el20/Inpp5d^el20
• Genetic Background: B6.129-Inpp5d^el20

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:173266 )

• no homozygotes survive beyond 7 weeks of age whereas Inpp5d^{tm1Dmt/tm1Dmt} mice show 50% survival at 6 months

growth/size/body

decreased body size ( J:173266 )

• exhibit runting at weaning although present in expected numbers

postnatal growth retardation ( J:173266 )

• failure to thrive after weaning

enlarged spleen ( J:173266 )

• due to increased erythropoiesis

respiratory system

abnormal pulmonary alveolus morphology ( J:173266 )

• alveoli of mice at 4 weeks of age are filled with lipid laden macrophage containing eosinophilic Ym1 crystals

respiratory failure ( J:173266 )

• of mice at 4 weeks of age

hematopoietic system

small thymus ( J:173266 )

• very small thymus

enlarged spleen ( J:173266 )

• due to increased erythropoiesis

abnormal erythropoiesis ( J:173266 )

• increased erythropoiesis

anemia ( J:173266 )

• in 4 week old mice

thrombocytopenia ( J:173266 )

• in 4 week old mice

abnormal lymphocyte cell number ( J:173266 )

decreased lymphocyte cell number ( J:173266 )

• significantly reduced circulating lymphocyte cell number at 4 weeks of age relative to Inpp5d^{tm1Dmt/tm1Dmt} mice

• reduction in mature B cells in bone marrow 4 weeks of age

decreased thymocyte number ( J:173266 )

• double positive thymocytes in particular are reduced

decreased pre-B cell number ( J:173266 )

• 50 fold reduction in pre-B cells in bone marrow 4 weeks of age

increased macrophage cell number ( J:173266 )

• 3 fold increase in Mac-1⁺Gr-1⁺

increased immunoglobulin level ( J:173266 )

increased IgG2a level ( J:173266 )

• increased IgGa at 4 weeks of age although overall IgG levels are normal

increased IgM level ( J:173266 )

• 53 fold increase in serum IgM at 4 weeks of age

immune system

small thymus ( J:173266 )

• very small thymus

enlarged spleen ( J:173266 )

• due to increased erythropoiesis

abnormal lymphocyte cell number ( J:173266 )

decreased lymphocyte cell number ( J:173266 )

• significantly reduced circulating lymphocyte cell number at 4 weeks of age relative to Inpp5d^{tm1Dmt/tm1Dmt} mice

• reduction in mature B cells in bone marrow 4 weeks of age

decreased thymocyte number ( J:173266 )

• double positive thymocytes in particular are reduced

decreased pre-B cell number ( J:173266 )

• 50 fold reduction in pre-B cells in bone marrow 4 weeks of age

increased macrophage cell number ( J:173266 )

• 3 fold increase in Mac-1⁺Gr-1⁺

increased immunoglobulin level ( J:173266 )

increased IgG2a level ( J:173266 )

• increased IgGa at 4 weeks of age although overall IgG levels are normal

increased IgM level ( J:173266 )

• 53 fold increase in serum IgM at 4 weeks of age

increased circulating interleukin-6 level ( J:173266 )

• circulating levels are 100 times greater than in controls an 3 times greater than in age matched Inpp5d^{tm1Dmt/tm1Dmt} mice

• elevated in bone marrow macrophage

homeostasis/metabolism

increased circulating interleukin-6 level ( J:173266 )

• circulating levels are 100 times greater than in controls an 3 times greater than in age matched Inpp5d^{tm1Dmt/tm1Dmt} mice

• elevated in bone marrow macrophage

endocrine/exocrine glands

small thymus ( J:173266 )

• very small thymus

decreased thymocyte number ( J:173266 )

• double positive thymocytes in particular are reduced