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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gopctm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:5051001
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gopctm1a(EUCOMM)Wtsi/Gopctm1a(EUCOMM)Wtsi C57BL/6-Gopctm1a(EUCOMM)Wtsi MGI:5780806


Genotype
MGI:5780806
hm1
Allelic
Composition
Gopctm1a(EUCOMM)Wtsi/Gopctm1a(EUCOMM)Wtsi
Genetic
Background
C57BL/6-Gopctm1a(EUCOMM)Wtsi
Cell Lines EPD0822_2_B04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gopctm1a(EUCOMM)Wtsi mutation (0 available); any Gopc mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only very few homozygotes are produced from heterozygous intercrosses (3 homozygotes; 138 heterozygotes; 81 wild-type); time of lethality is not specified

cellular
• a significant reduction of beta1-adrenergic receptor levels is observed in hippocampal lysates, suggesting that Gopc stabilizes its interacting G-protein-coupled receptors





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory