Phenotypes associated with this allele

• Allele Symbol: Ptgds^{tm1.1(cre)Gvn}
• Allele Name: targeted mutation 1.1, Marco Giovannini
• Allele ID: MGI:5051626
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nf2^tm2Gth/Nf2^tm2Gth Ptgds^tm1.1(cre)Gvn/Ptgds^+	involves: 129P2/OlaHsd * FVB/N	MGI:5051641
cn2	Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn Nf2^tm2Gth/Nf2^tm2Gth Ptgds^tm1.1(cre)Gvn/Ptgds^+	involves: 129P2/OlaHsd * FVB/N	MGI:5051643
cn3	Nf2^tm2Gth/Nf2^tm2Gth Ptgds^tm1.1(cre)Gvn/Ptgds^+ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * FVB/N	MGI:5051644
cn4	Ano3^tm1.1Lyj/Ano3^tm1.1Lyj Ptgds^tm1.1(cre)Gvn/Ptgds^+	involves: 129X1/SvJ * C57BL/6 * FVB/N	MGI:6790233

Genotype
MGI:5051641

cn1

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

mortality/aging

mortality/aging ( J:173718 )

N • mice are born at normal Mendelian frequencies, are viable, and show comparable survival to control littermates (>75% survive to 10 months)

neoplasm

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

increased meningioma incidence ( J:173718 )

• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem

increased osteoma incidence ( J:173718 )

• observed in 81% of mice examined

nervous system

increased pituitary adenoma incidence ( J:173718 )

• observed in 69% of mice examined

increased meningioma incidence ( J:173718 )

• meningiomas are frequently observed; development is restricted to base of skull ventral to brainstem

skeleton

increased osteoma incidence ( J:173718 )

• observed in 81% of mice examined

Genotype
MGI:5051643

cn2

• Allelic Composition: Cdkn2a^tm1.1Brn/Cdkn2a^tm1.1Brn; Nf2^tm2Gth/Nf2^tm2Gth; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

nervous system

increased meningioma incidence ( J:173718 )

• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals

mortality/aging

mortality/aging ( J:173718 )

N • mice show similar survival/lifespan to Cdkn2a-sufficient animals

neoplasm

neoplasm ( J:173718 )

N • no pituitary tumors are observed

increased meningioma incidence ( J:173718 )

• mice develop a slightly higher number of meningiomas (not statistically significant) relative to Cdkn2a-sufficient animals

Genotype
MGI:5051644

cn3

• Allelic Composition: Nf2^tm2Gth/Nf2^tm2Gth; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺; Trp53^tm1Brn/Trp53^tm1Brn
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

mortality/aging

premature death ( J:173718 )

• survival is significantly shortened relative to Trp53-sufficient Nf2-deficient mice (almost complete mortality by about 7 months of age)

neoplasm

increased osteosarcoma incidence ( J:173718 )

• mice develop aggressive osteosarcomas early in life, likely reducing survival time

increased nervous system tumor incidence ( J:173718 )

• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time

skeleton

increased osteosarcoma incidence ( J:173718 )

• mice develop aggressive osteosarcomas early in life, likely reducing survival time

nervous system

increased nervous system tumor incidence ( J:173718 )

• development of malignant peripheral nerve sheath tumours (MPNST) and choroid plexus carcinoma is also seen in some animals, likely reducing survival time

Genotype
MGI:6790233

cn4

• Allelic Composition: Ano3^tm1.1Lyj/Ano3^tm1.1Lyj; Ptgds^{tm1.1(cre)Gvn}/Ptgds⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

behavior/neurological

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures

homeostasis/metabolism

abnormal body temperature homeostasis ( J:310618 )

• P11 mice exhibit a more rapid core temperature increase upon heat exposure

• P11 mice exhibit lower core temperature at ambient temperature of 22 or 30 degrees Celsius, but core temperature is comparable to wild-type controls when the ambient temperature is held at 37 degrees C

• the slopes of core temperature change with ambient temperature manipulation differs from controls

nervous system

environmentally induced seizures ( J:310618 )

• P11 pups exhibit a greater susceptibility to hyperthermia-induced seizures

• however, mice show comparable susceptibility to chemoconvulsant-induced seizures