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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnase10tm1(cre)Hht
targeted mutation 1, Ilpo Huhtaniemi
MGI:5051834
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Artm1Verh/Y
Rnase10tm1(cre)Hht/Rnase10+ 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5051914


Genotype
MGI:5051914
cn1
Allelic
Composition		 Artm1Verh/Y
Rnase10tm1(cre)Hht/Rnase10+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Verh mutation (1 available); any Ar mutation (23 available)
Rnase10tm1(cre)Hht mutation (0 available); any Rnase10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
seminiferous tubule degeneration ( J:173897 )
• undergoing degeneration at 4 months
• germinal epithelium lost in many tubules
• intraepithelial cysts frequently found
enlarged testis ( J:173897 )
• at four months
• as a result of fluid retention
abnormal epididymis morphology ( J:173897 )
• spermatic granulomata frequently obstruct the epididymes
abnormal caput epididymis morphology ( J:173897 )
• initial segment hypoplasia by 30 days
• epididymis becomes obstructed at the level of the caput
• sperm build-up starting around 40 days causes severe dilation and finally, complete occlusion
abnormal epididymis epithelium morphology ( J:173897 )
• decreased height after 20-25 days in segments I and II
epididymis epithelium degeneration ( J:173897 )
• begins to degenerate distal to occlusion
testis inflammation ( J:173897 )
• some males develop unilateral orchitis
male infertility ( J:173897 )
• no pregnancies after mating to CD1 females
• vaginal plugs are produced

endocrine/exocrine glands
seminiferous tubule degeneration ( J:173897 )
• undergoing degeneration at 4 months
• germinal epithelium lost in many tubules
• intraepithelial cysts frequently found
enlarged testis ( J:173897 )
• at four months
• as a result of fluid retention
testis inflammation ( J:173897 )
• some males develop unilateral orchitis

immune system
testis inflammation ( J:173897 )
• some males develop unilateral orchitis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory