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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm4dtm1Zuk
targeted mutation 1, Martin M Matzuk
MGI:5051955
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm4dtm1Zuk/Kdm4dtm1Zuk involves: 129S7/SvEvBrd * C57BL/6J MGI:5051961


Genotype
MGI:5051961
hm1
Allelic
Composition		 Kdm4dtm1Zuk/Kdm4dtm1Zuk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm4dtm1Zuk mutation (0 available); any Kdm4d mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:173703 )
N
• male mice exhibit normal fertility
abnormal spermatid morphology ( J:173703 )
• spermatids exhibit an accumulation of histone 3 methylation (H3K9me3) compared to in wild-type cells
abnormal male germ cell apoptosis ( J:173703 )
• occasionally in testes of mice older than 10 weeks at low frequencies
enlarged seminiferous tubules ( J:173703 )
• wider diameter at 3 weeks but not in older mice
enlarged testis ( J:173703 )
• transiently at 12 weeks

growth/size/body
decreased body weight ( J:173703 )
• at 16 and 52 weeks of age

endocrine/exocrine glands
enlarged seminiferous tubules ( J:173703 )
• wider diameter at 3 weeks but not in older mice
enlarged testis ( J:173703 )
• transiently at 12 weeks

cellular
abnormal spermatid morphology ( J:173703 )
• spermatids exhibit an accumulation of histone 3 methylation (H3K9me3) compared to in wild-type cells
abnormal male germ cell apoptosis ( J:173703 )
• occasionally in testes of mice older than 10 weeks at low frequencies




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory