Phenotypes associated with this allele

• Allele Symbol: Phb1^tm1.1Bwo
• Allele Name: targeted mutation 1.1, Bert W O'Malley
• Allele ID: MGI:5051969
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Phb1^tm1.1Bwo/Phb1^tm1.1Bwo Pgr^tm2(cre)Lyd/?	involves: 129S7/SvEvBrd * C57BL/6	MGI:5052044

Genotype
MGI:5052044

cn1

• Allelic Composition: Phb1^tm1.1Bwo/Phb1^tm1.1Bwo; Pgr^tm2(cre)Lyd/?
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal uterus morphology ( J:173884 )

♀

abnormal endometrium morphology ( J:173884 )

♀ • endometrium is significantly reduced although uterine structure is otherwise normal

♀ • luminal and glandular epithelial cells are present

♀ • endometrium does respond to estradiol

endometrium hypoplasia ( J:173884 )

♀

thin uterine horn ( J:173884 )

♀ • circumference of uterine horns is significantly reduced although length is normal

abnormal uterus size ( J:173884 )

♀

decreased uterus weight ( J:173884 )

♀ • uterus to body weight ratio is significantly reduced by 5 weeks of age

♀ • estradiol has little effect on uterine growth

female infertility ( J:173884 )

♀ • when Phb expression is ablated in the uterus, female mice are sterile

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:173884 )

N • serum estradiol levels are normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:173884 )

N • ovarian morphology is apparently normal