Phenotypes associated with this allele

• Allele Symbol: Ebf2^tm1Ddr
• Allele Name: targeted mutation 1, D J Drucker
• Allele ID: MGI:5052069
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ebf2^tm1Ddr/Ebf2^tm1Ddr	129S2/SvPas-Ebf2^tm1Ddr	MGI:5052072

Genotype
MGI:5052072

hm1

• Allelic Composition: Ebf2^tm1Ddr/Ebf2^tm1Ddr
• Genetic Background: 129S2/SvPas-Ebf2^tm1Ddr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neurite morphology ( J:173959 )

• neurons exhibit abnormal orexinergic projections compared with wild-type cells

decreased neuron number ( J:173959 )

• mice exhibit decreased number of orexinergic neurons compared with wild-type mice

behavior/neurological

narcolepsy ( J:173959 )

• mice exhibit direct transition to rapid eye movement (DREM) episodes with a predominant theta frequency and more fragmented non-REM sleep episodes compared with wild-type mice

• mice spend more time in nREM, REM sleep, and much less time in wake compared with wild-type mice

• mice exhibit shorter REM latency compared with wild-type mice

• however, treatment with orexin A (Hcrt) peptide reverts narcoleptic phenotype