Phenotypes associated with this allele

• Allele Symbol: Tg(CMV-SART3)#Hbro
• Allele Name: transgene insertion, Hal E Broxmeyer
• Allele ID: MGI:5052107
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CMV-SART3)#Hbro/0	Not Specified	MGI:5052128

Genotype
MGI:5052128

tg1

• Allelic Composition: Tg(CMV-SART3)#Hbro/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:173259 )

• mice exhibit a higher percentage of hematopoietic progenitor cells in the bone marrow and spleen cells in the S phase compared with wild-type mice

• HPCs from 5-FU-treated mice are less protected than HPCs from wild-type mice

abnormal common myeloid progenitor cell morphology ( J:173259 )

• mice exhibit increased colony forming units granulocyte, erythrocyte, macrophage, and megakaryocyte (CFU-GEMM) and granulocyte-macrophage (CFU-GM) compared with wild-type mice

• after 11 days, 5-FU-treated mice exhibit reduced CFU-GMs and CFU-GEMMs compared with similarly treated wild-type mice

decreased erythroid progenitor cell number ( J:173259 )

increased erythroid progenitor cell number ( J:173259 )

• 11 days after 5-FU treatment