Phenotypes associated with this allele

• Allele Symbol: Lcn2^tm1Mrgr
• Allele Name: targeted mutation 1, Michael R Green
• Allele ID: MGI:5052158
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lcn2^tm1Mrgr/Lcn2^tm1Mrgr	129(B6)-Lcn2^tm1Mrgr	MGI:5052263
hm2	Lcn2^tm1Mrgr/Lcn2^tm1Mrgr	B6.129-Lcn2^tm1Mrgr	MGI:5052264
hm3	Lcn2^tm1Mrgr/Lcn2^tm1Mrgr	involves: 129 * C57BL/6	MGI:5052265

Genotype
MGI:5052263

hm1

• Allelic Composition: Lcn2^tm1Mrgr/Lcn2^tm1Mrgr
• Genetic Background: 129(B6)-Lcn2^tm1Mrgr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:173490 )

N • mice exhibit normal response to 5-FU treatment

decreased thymocyte apoptosis ( J:173490 )

• spontaneous or dexamethasome-induced

thymus hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

spleen hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

abnormal erythropoiesis ( J:173490 )

• Ter-119+ cells exhibit decreased apoptosis compared to in wild-type mice

abnormal myelopoiesis ( J:173490 )

• Gr-1+ cells exhibit a reduced rate of spontaneous and G-CSF deprivation-induced apoptosis compared with wild-type cells

myeloid hyperplasia ( J:173490 )

• aged mice exhibit enhanced myelopoiesis develop neutrophilia unlike wild-type mice

increased bone marrow cell number ( J:173490 )

• mice exhibit a 1.5-fold increase in bone marrow cell compared with wild-type mice

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

increased erythroid progenitor cell number ( J:173490 )

• mice exhibit increased Ter-119+ and burst forming unit erythroid cells in the peripheral blood, bone marrow, and spleen compared with wild-type mice

increased erythroblast number ( J:173490 )

• 3-fold

increased erythrocyte cell number ( J:173490 )

• in adult and aged mice

increased hematocrit ( J:173490 )

increased mean corpuscular hemoglobin ( J:173490 )

thrombocytopenia ( J:173490 )

increased leukocyte cell number ( J:173490 )

• mice exhibit a 1.96-fold increase in white blood cell compared with wild-type mice

• the increase in white blood cell is severe in wild-type mice transplanted with bone marrow from homozygous mice

• at 18 months, mice exhibit increased white blood cells compared with wild-type mice

• however, the number of basophils is normal

increased neutrophil cell number ( J:173490 )

• in wild-type mice transplanted with bone marrow from homozygous mice

• 4.3-fold in aged mice due to enhanced myelopoiesis

increased lymphocyte cell number ( J:173490 )

• in wild-type mice transplanted with bone marrow from homozygous mice

• in aged mice

increased B cell number ( J:173490 )

• in the bone marrow and spleen

increased macrophage cell number ( J:173490 )

• mice exhibit an increase in Gr-1+/Mac-1+ cells compared with wild-type mice

increased monocyte cell number ( J:173490 )

• mild in wild-type mice transplanted with bone marrow from homozygous mice

• 1.75-fold in aged mice

increased splenocyte number ( J:173490 )

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a congenic 129 background exhibit a greater reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a C57BL/6 congenic or mixed 129 and C57BL/6 background

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

cellular

decreased apoptosis ( J:173490 )

• mice exhibit reduced apoptosis in Ter-119+ cells, thymocytes, neutrophils, and mast cells compared with wild-type mice

decreased thymocyte apoptosis ( J:173490 )

• spontaneous or dexamethasome-induced

immune system

decreased thymocyte apoptosis ( J:173490 )

• spontaneous or dexamethasome-induced

thymus hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

spleen hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

abnormal myelopoiesis ( J:173490 )

• Gr-1+ cells exhibit a reduced rate of spontaneous and G-CSF deprivation-induced apoptosis compared with wild-type cells

myeloid hyperplasia ( J:173490 )

• aged mice exhibit enhanced myelopoiesis develop neutrophilia unlike wild-type mice

increased leukocyte cell number ( J:173490 )

• mice exhibit a 1.96-fold increase in white blood cell compared with wild-type mice

• the increase in white blood cell is severe in wild-type mice transplanted with bone marrow from homozygous mice

• at 18 months, mice exhibit increased white blood cells compared with wild-type mice

• however, the number of basophils is normal

increased neutrophil cell number ( J:173490 )

• in wild-type mice transplanted with bone marrow from homozygous mice

• 4.3-fold in aged mice due to enhanced myelopoiesis

increased lymphocyte cell number ( J:173490 )

• in wild-type mice transplanted with bone marrow from homozygous mice

• in aged mice

increased B cell number ( J:173490 )

• in the bone marrow and spleen

increased macrophage cell number ( J:173490 )

• mice exhibit an increase in Gr-1+/Mac-1+ cells compared with wild-type mice

increased monocyte cell number ( J:173490 )

• mild in wild-type mice transplanted with bone marrow from homozygous mice

• 1.75-fold in aged mice

increased splenocyte number ( J:173490 )

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a congenic 129 background exhibit a greater reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a C57BL/6 congenic or mixed 129 and C57BL/6 background

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:173490 )

• spontaneous or dexamethasome-induced

thymus hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

growth/size/body

spleen hyperplasia ( J:173490 )

• dexamethasome-treated mice exhibit increased thymic, splenic, and bone marrow cellularity compared with similarly treated wild-type mice

Genotype
MGI:5052264

hm2

• Allelic Composition: Lcn2^tm1Mrgr/Lcn2^tm1Mrgr
• Genetic Background: B6.129-Lcn2^tm1Mrgr

immune system

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a congenic C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 congenic background

hematopoietic system

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a congenic C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 congenic background

Genotype
MGI:5052265

hm3

• Allelic Composition: Lcn2^tm1Mrgr/Lcn2^tm1Mrgr
• Genetic Background: involves: 129 * C57BL/6

immune system

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 or C57BL/6 congenic background

hematopoietic system

abnormal mast cell physiology ( J:173490 )

• bone marrow-derived mast cells exhibit reduced apoptosis induced by cytokine deprivation compared with wild-type cells

• Background Sensitivity: mice on a mixed 129 and C57BL/6 background exhibit less of a reduction in mast cell apoptosis induced by cytokine deprivation compared with mice on a 129 or C57BL/6 congenic background