Phenotypes associated with this allele

• Allele Symbol: Clec4a2^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052160
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4a2^tm1.1Cfg/Clec4a2^tm1.1Cfg	involves: C57BL/6	MGI:5615600

Genotype
MGI:5615600

hm1

• Allelic Composition: Clec4a2^tm1.1Cfg/Clec4a2^tm1.1Cfg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

seminiferous tubule degeneration ( J:217719 )

♂ • in older mice

immune system

immune system phenotype ( J:217719 )

N • older mice exhibit normal autoantibody levels

N • mice exhibit normal CD11c+ populations in the lymph node

increased B cell proliferation ( J:217719 )

• after stimulation by either anti-IgM or LPS

increased IgG2a level ( J:217719 )

• when stimulated with a T-independent antigen

increased IgG2b level ( J:217719 )

• when stimulated with a T-independent antigen

increased IgG3 level ( J:217719 )

• when stimulated with a T-independent antigen

enlarged lymph nodes ( J:217719 )

• slightly

increased inflammatory response ( J:217719 )

• in older mice in the salivary gland

skeleton

skeleton phenotype ( J:217719 )

N • mice exhibit normal joints

endocrine/exocrine glands

seminiferous tubule degeneration ( J:217719 )

♂ • in older mice

hematopoietic system

increased B cell proliferation ( J:217719 )

• after stimulation by either anti-IgM or LPS

increased IgG2a level ( J:217719 )

• when stimulated with a T-independent antigen

increased IgG2b level ( J:217719 )

• when stimulated with a T-independent antigen

increased IgG3 level ( J:217719 )

• when stimulated with a T-independent antigen

cellular

increased B cell proliferation ( J:217719 )

• after stimulation by either anti-IgM or LPS