Phenotypes associated with this allele

• Allele Symbol: Cd209d^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052162
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd209d^tm1.1Cfg/Cd209d^tm1.1Cfg	involves: C57BL/6	MGI:5615606
hm2	Cd209d^tm1.1Cfg/Cd209d^tm1.1Cfg	involves: C57BL/6 * C57BL/6J	MGI:4366045

Genotype
MGI:5615606

hm1

• Allelic Composition: Cd209d^tm1.1Cfg/Cd209d^tm1.1Cfg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:217719 )

• following anti-IgM stimulation

increased B cell number ( J:217719 )

• IgG+ IgM+ B cells in the spleen

• slight increase in B220+ CD22+ cells

adipose tissue

abnormal fat cell morphology ( J:217719 )

• increased adipocyte numbers in the bone marrow at 12 weeks and 1 year of age

hematopoietic system

increased B cell proliferation ( J:217719 )

• following anti-IgM stimulation

increased B cell number ( J:217719 )

• IgG+ IgM+ B cells in the spleen

• slight increase in B220+ CD22+ cells

cellular

increased B cell proliferation ( J:217719 )

• following anti-IgM stimulation

Genotype
MGI:4366045

hm2

• Allelic Composition: Cd209d^tm1.1Cfg/Cd209d^tm1.1Cfg
• Genetic Background: involves: C57BL/6 * C57BL/6J

immune system

increased circulating tumor necrosis factor level ( J:153503 )

• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:153503 )

• 21 days after infection with M. tuberculosis, lung bacterial counts are 5 to 31 times in similarly treated wild-type mice

• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice

• 42 days after infection with M. tuberculosis, lung bacterial counts are 3 to 12 times in similarly treated wild-type mice

• however, M. tuberculosis infected mice exhibit normal bacterial colonization of the spleen, formation of granulomatous lesions, and mortality

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:153503 )

• 21 days post-infection with M. tuberculosis, mice exhibit lower TNF levels compared with similarly treated wild-type mice