Phenotypes associated with this allele

• Allele Symbol: Clec4d^tm1.1Cfg
• Allele Name: targeted mutation 1.1, Consortium for Functional Glycomics
• Allele ID: MGI:5052163
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4d^tm1.1Cfg/Clec4d^tm1.1Cfg	involves: C57BL/6	MGI:3706434

Genotype
MGI:3706434

hm1

• Allelic Composition: Clec4d^tm1.1Cfg/Clec4d^tm1.1Cfg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:203221 )

• mice infected with Klebsiella pneumonia die before wild-type mice

immune system

immune system phenotype ( J:203221 )

N • mice exhibit normal neutrophil infiltration, phagocytosis of opsonized or nonosponized bacteria and activation of neutrophils

decreased B cell proliferation ( J:217719 )

• following receptor crosslinking

decreased T cell proliferation ( J:217719 )

• following receptor crosslinking

increased B cell number ( J:217719 )

• elevated frequencies of CD19+, CD22+ cells; B220^hi, CD19+ cells; IgD SP cells and B220^hi,CD24^lo cells

increased mature B cell number ( J:217719 )

• potential increase in mature recirculating B cells in the bone marrow

increased interferon-gamma secretion ( J:203221 )

• in the lungs at 3 and 5 days post-infection with Klebsiella pneumonia

increased interleukin-10 secretion ( J:203221 )

• in the lungs at only 3 days post-infection with Klebsiella pneumonia

increased interleukin-17 secretion ( J:203221 )

• in the lungs at 3 and 5 days post-infection with Klebsiella pneumonia

increased interleukin-6 secretion ( J:203221 )

• in the lungs at 3 and 5 days post-infection with Klebsiella pneumonia

increased tumor necrosis factor secretion ( J:203221 )

• in the lungs at 3 and 5 days post-infection with Klebsiella pneumonia

lung inflammation ( J:203221 )

• progressively increasing lung leukocyte infiltration 3 and 5 days post-infection with Klebsiella pneumonia

increased susceptibility to bacterial infection ( J:203221 )

• mice infected with Klebsiella pneumonia die before wild-type mice, exhibit increased bacterial load, progressively increasing levels of inflammatory cytokines (TNFalpha, IFNgamma, IL6 and IL17) in the lungs and progressively increasing lung leukocyte infiltration, and fail to recover from low doses unlike wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:203221 )

• mice infected with Klebsiella pneumonia die before wild-type mice

respiratory system

lung inflammation ( J:203221 )

• progressively increasing lung leukocyte infiltration 3 and 5 days post-infection with Klebsiella pneumonia

hematopoietic system

decreased B cell proliferation ( J:217719 )

• following receptor crosslinking

decreased T cell proliferation ( J:217719 )

• following receptor crosslinking

extramedullary hematopoiesis ( J:217719 )

• in the spleen

increased B cell number ( J:217719 )

• elevated frequencies of CD19+, CD22+ cells; B220^hi, CD19+ cells; IgD SP cells and B220^hi,CD24^lo cells

increased mature B cell number ( J:217719 )

• potential increase in mature recirculating B cells in the bone marrow

cellular

decreased B cell proliferation ( J:217719 )

• following receptor crosslinking

decreased T cell proliferation ( J:217719 )

• following receptor crosslinking